多胚瘤
Polyembryoma
ORPHA:180229疾病
定义 英文原文（暂无中文）
A rare malignant germ cell tumor characterized by predominant composition of embryoid bodies consisting of a central core of embryonal carcinoma cells, an amnion-like cavity, and a yolk sac tumor component. The tumor usually occurs as the dominant component of a mixed germ cell tumor, with teratoma being the most common associated element. It may manifest as an abdominal mass or with abdominal pain, menstrual irregularities, or precocious puberty in women, while men typically present with testicular enlargement. Serum alpha-fetoprotein and/or beta-human chorionic gonadotropin can be elevated.
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 青少年期、成年期
- 患病率
- <1 / 1 000 000（Europe）
临床表型 19
常见 79–30%3
- 循环促性腺激素浓度异常 HP:0030338
- 性腺肿瘤 HP:0010785
- 神经外胚层肿瘤 HP:0030061
偶见 29–5%8
- 腹部肿块 HP:0031500
- 腹痛 HP:0002027
- 纵隔形态异常 HP:0045026
- 异常出血 HP:0040231
- 骶骨形态异常 HP:0005107
- 腹膜形态异常 HP:0002585
- 循环甲胎蛋白浓度升高 HP:0006254
- 头颈部肿瘤 HP:0012288
罕见 <4–1%8
- 腹胀 HP:0003270
- 内分泌系统异常 HP:0000818
- 发热 HP:0001945
- 血清5-羟色胺（血清素）水平升高 HP:0003144
- 血清睾酮水平增高 HP:0030088
- 月经不调 HP:0000858
- 同性性早熟 HP:0008236
- 巨睾 HP:0000053
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）