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淋巴性丝虫病

Lymphatic filariasis

ORPHA:2035疾病

定义 英文原文(暂无中文)

Lymphatic filariasis (LF) is a severe form of filariasis, caused by the parasitic worms Wuchereria bancrofti, Brugia malayi and Brugia timori, and the most common cause of acquired lymphedema worldwide. LF is endemic to tropical and subtropical regions. The vast majority of infected patients are asymptomatic but it can also cause a variety of clinical manifestations, including limb lymphedema, genital anomalies (hydrocele, chylocele), elephantiasis in later stages of the disease (frequently in the lower extremities), and tropical pulmonary eosinophilia (nocturnal paroxysmal cough and wheezing, weight loss, low-grade fever, adenopathy, and pronounced blood eosinophilia). Renal involvement (hematuria, proteinuria, nephritic syndrome, glomerulonephritis), and mono-arthritis of the knee or ankle joint have also been reported.

基本事实

遗传方式
不适用
发病年龄
各年龄段
患病率
>1 / 1000(Specific population)

临床表型 33

极常见 99–80%4

  • 淋巴系统异常 HP:0100763
  • 淋巴结肿大 HP:0002716
  • 淋巴水肿 HP:0001004
  • 主要累及下肢的淋巴水肿 HP:0003550

常见 79–30%7

  • 循环免疫复合物 HP:0012224
  • 疲乏 HP:0012378
  • 高嗜酸性粒细胞 HP:0032061
  • 角化过度 HP:0000962
  • 皮肤色素沉着 HP:0000953
  • 淋巴结炎 HP:0002840
  • 疼痛 HP:0012531

偶见 29–5%13

  • 肺部形态异常 HP:0002088
  • 肾脏异常 HP:0000077
  • 阴囊形态异常 HP:0000045
  • 咳嗽 HP:0012735
  • 发热 HP:0001945
  • 睾丸鞘膜积液 HP:0000034
  • 淋巴管扩张 HP:0031842
  • 机会性细菌感染 HP:0032260
  • 机会性感染 HP:0031690
  • 睾丸炎 HP:0100796
  • 限制性通气功能障碍 HP:0002091
  • 阴道积液 HP:0100673
  • 哮鸣音 HP:0030828

罕见 <4–1%9

  • 踝关节肿胀 HP:0001785
  • 附睾炎 HP:0000031
  • 肾小球肾炎 HP:0000099
  • 血尿 HP:0000790
  • 膝关节骨性关节炎 HP:0005086
  • 肾病综合征 HP:0000100
  • 无社会交往 HP:0008763
  • 蛋白尿 HP:0000093
  • 尿道梗阻 HP:0000796

外部标识与链接

OrphanetGARD:3321ICD-10 B74.0、B74.1、B74.2ICD-11 1F66.3、1F66.30、1F66.31、1F66.32ClinicalTrials.gov 检索

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本页数据来源

  • 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
  • 中文病名:Orphanet 中文包,冻结于 2020-06-01
  • 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)