成人肝细胞癌

Adult hepatocellular carcinoma

ORPHA:210159疾病

定义

成人肝癌是一种罕见的肿瘤性疾病，也是成年期最常见的原发性肝癌，其主要临床表现为肝肿块、腹痛，晚期出现黄疸、恶病质和肝功能衰竭。该病起源于分化良好的肝细胞，然后发展为慢性肝硬化，肝硬化最常见的病因是乙型和丙型肝炎病毒或酗酒。

成人HCC

基因	名称	关联类型
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Disease-causing somatic mutation(s) in
TP53	tumor protein p53	Candidate gene tested in
TSC1	TSC complex subunit 1	Candidate gene tested in
TSC2	TSC complex subunit 2	Candidate gene tested in
CTNNB1	catenin beta 1	Candidate gene tested in
CASP8	caspase 8	Disease-causing somatic mutation(s) in
EGF	epidermal growth factor	Major susceptibility factor in
AXIN1	axin 1	Disease-causing somatic mutation(s) in
PDGFRL	platelet derived growth factor receptor like	Candidate gene tested in

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