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特发性肺动脉高压

Idiopathic pulmonary arterial hypertension

ORPHA:275766疾病亚型中国目录 第1批 · 54

定义

特发性肺动脉高压(IPAH)是一种散发性肺动脉高压(PAH),其特征与肺动脉阻力升高导致右心衰竭相关。IPAH是进行性的,具有潜在的致命性,与潜在疾病或PAH家族史无关。

别名

原发性肺动脉高压

基本事实

遗传方式
不适用
发病年龄
各年龄段
患病率
1-9 / 1 000 000

临床表型 18

必现 100%1

  • 呼吸困难 HP:0002094

极常见 99–80%5

  • 颈静脉形态异常 HP:3000042
  • 肺动脉压升高 HP:0004890
  • 肺血管阻力增加 HP:0005317
  • 肺动脉高压 HP:0002092
  • 右心室肥厚 HP:0001667

常见 79–30%7

  • 踝关节肿胀 HP:0001785
  • 胸痛 HP:0100749
  • 充血性心力衰竭 HP:0001635
  • 足背水肿 HP:0012098
  • 心脏杂音 HP:0030148
  • 晕厥 HP:0001279
  • 三尖瓣反流 HP:0005180

偶见 29–5%3

  • 咯血 HP:0002105
  • 心悸 HP:0001962
  • 下肢水肿 HP:0010741

排除 0%2

  • 结缔组织异常 HP:0003549
  • 慢性溶血性贫血 HP:0004870

近两年的全球研究 577L2

2024/08 起在 Europe PMC 检索所得,按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务,尚未引入。

  • 2026-08病例报告
    Sheehan Syndrome as a Hidden Cause of Postpartum Clinical Deterioration in Severe Idiopathic Pulmonary Arterial Hypertension
    Archivos de bronconeumologia · DOI · Europe PMC
  • 2026-07
    Phenotypic Clustering of Idiopathic Pulmonary Arterial Hypertension: Insights Into Pulmonary Vascular and Cardiometabolic Co-Morbidity Trajectories
    Pulmonary circulation · DOI · Europe PMC
  • 2026-07随机对照试验
    Empagliflozin Ameliorates Experimental Pulmonary Vascular Remodeling, but May Not Benefit Patients With Pulmonary Arterial Hypertension
    Journal of the American Heart Association · DOI · Europe PMC
  • 2026-07
    Integrated transcriptomic and machine learning analysis identifies female-associated candidate biomarkers in Idiopathic pulmonary arterial hypertension
    Computational biology and chemistry · DOI · Europe PMC
  • 2026-07
    Misdiagnosed as Idiopathic PAH: Methylmalonic Acidemia as a Reversible Cause of Pediatric Pulmonary Hypertension
    The Journal of heart and lung transplantation : the official publicati · DOI · Europe PMC
  • 2026-07
    Divergent Inflammatory and Bioenergetic Metabolomic Signatures Distinguish Methamphetamine-Associated From Idiopathic Pulmonary Arterial Hypertension
    Pulmonary circulation · DOI · Europe PMC
  • 2026-07综述
    Comparison of Functional and Hemodynamic Parameters Between Methamphetamine-Associated and Idiopathic Pulmonary Arterial Hypertension: Systematic Review and Meta-Analysis
    Healthcare (Basel, Switzerland) · DOI · Europe PMC
  • 2026-07
    Alterations in the fecal virome and bacteriome-virome interplay in IPAH
    Respiratory research · DOI · Europe PMC
  • 2026-06综述
    Pulmonary hypertension following lung transplant: a systematic review
    Journal of thoracic disease · DOI · Europe PMC
  • 2026-06开放获取
    ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension
    Journal of cardiovascular development and disease · DOI · Europe PMC
  • 2026-06开放获取
    Dissection of the pulmonary artery: a rare complication
    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Bra · DOI · Europe PMC
  • 2026-06开放获取
    Predictive Value of the Pulmonary Artery Pulsatility Index in Pulmonary Arterial Hypertension: REVEAL Analysis
    Cardiology research · DOI · Europe PMC
  • 2026-05综述开放获取
    Molecular-Genetic Basis of Pulmonary Arterial Hypertension (PAH)
    Current issues in molecular biology
  • 2026-05综述开放获取
    The Role of Platelets in Pulmonary Hypertension: From Activation to Pulmonary Vascular Remodeling—A Review Article
    Biomedicines
  • 2026-05
    Characterization of CT Imaging-Derived Pulmonary Vascular Abnormalities Associated With Pulmonary Hypertension in Chronic Lung Disease
    Chest · DOI · Europe PMC
  • 2026-05
    Hypoxia Upregulation of BACH1 Aggravates Pulmonary Hypertension Through TGFBR2/SMAD Pathways
    Circulation · DOI · Europe PMC
  • 2026-05综述开放获取
    O-GlcNAcylation as a Metabolic Integrator in Cardiovascular Physiology and Disease
    International journal of molecular sciences · DOI · Europe PMC
  • 2026-05病例报告开放获取
    A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo Heterozygous <i>CAV1</i> Mutation in a Pediatric Patient
    Children (Basel, Switzerland) · DOI · Europe PMC
  • 2026-05
    Integrated Single-Cell Atlas Reveals Cross-Subtype Heterogeneity in Human Pulmonary Hypertension
    Arteriosclerosis, thrombosis, and vascular biology · 被引 1 · DOI · Europe PMC
  • 2026-05开放获取
    The Role of the Cellular Communication Network Protein Family in Pulmonary Arterial Hypertension
    Pulmonary circulation · DOI · Europe PMC

境外已获批用于本病的药物 23L2

欧盟 10 项、美国 13 项。同一药物在两地各批一次的,会分别列出。

「境外已获批」不等于「在中国能用」。中间隔着进口注册、临床急需境外新药通道、海南博鳌乐城国际医疗旅游先行区等几条路径,各有各的条件与费用。这一节能确定地告诉你的只有一件事:这个病在世界范围内已经有获得批准的药物,它叫什么名字。拿这个名字去问主治医生,是下一步最省力的做法。

药名一律保留英文原文,不作翻译——中国的药品通用名与英文名的音译经常不一致,译错会让人去找一个不存在的药。

已获孤儿药资格、尚未获批的在研药物(55 项)

孤儿药资格只是一种监管身份——它意味着监管机构认可这是罕见病用药并给予研发激励,不代表这个药已被证明有效,也不代表将来一定能上市。绝大多数最终不会成药。列在这里是为了看清有哪些方向正在被尝试。

  • vasoactive Intestinal Peptide欧盟2003-12-22
    Treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    官方记录
  • Tyvaso; Tyvaso欧盟2004-04-14
    treprostinil sodium
    Treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    官方记录
  • Orepaxam欧盟2005-08-26
    treprostinil diethanolamine
    Treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    官方记录
  • Elafin欧盟2007-03-20
    Treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    官方记录
  • terguride欧盟2007-11-29
    Treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    官方记录
  • Lisuride hydrogen maleate欧盟2011-05-13
    Treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    官方记录
  • sodium nitrite欧盟2012-03-05
    Treatment of pulmonary arterial hypertension
    官方记录
  • ubenimex欧盟2016-03-21
    Treatment of pulmonary arterial hypertension
    官方记录
  • (S)-8-{2-amino-6-[1-(5-chloro-biphenyl-2-yl)-(R)-2,2,2-trifluoro-ethox欧盟2017-04-20
    Treatment of pulmonary arterial hypertension
    官方记录
  • tacrolimus欧盟2017-08-23
    Treatment of pulmonary arterial hypertension
    官方记录
  • N-(tert-butylcarbamoyl)-5-cyano-2-((4'-(difluoromethoxy)-[1,1'-bipheny欧盟2018-02-22
    Treatment of pulmonary arterial hypertension
    官方记录
  • ralinepag欧盟2019-01-11
    Treatment of pulmonary arterial hypertension
    官方记录
  • (S)-3-((3-(1-((6-(3,4-dimethoxyphenyl)pryazin-2-yl)amino)ethyl)phenyl)欧盟2019-05-29
    Treatment of pulmonary arterial hypertension
    官方记录
  • imatinib欧盟2021-06-21
    Treatment of pulmonary arterial hypertension
    官方记录
  • anti-(endothelin-1 receptor subtype A) IgG4 humanised monoclonal antib欧盟2021-12-10
    Treatment of pulmonary arterial hypertension
    官方记录
  • sodium valproate欧盟2024-08-21
    Treatment of pulmonary arterial hypertension
    官方记录
  • Sitaxsentan Sodium美国2004-11-02
    For the treatment of pulmonary arterial hypertension in the absence of chronic obstructive pulmonary disease or congestive heart failure.
    官方记录
  • aviptadil美国2005-02-22
    Treatment of pulmonary arterial hypertension
    官方记录
  • 2-methoxyestradiol美国2005-04-11
    Treatment of pulmonary arterial hypertension
    官方记录
  • sodium nitrite美国2008-07-08
    Treatment of pulmonary arterial hypertension
    官方记录
  • sodium dichloroacetate美国2010-11-29
    For pulmonary arterial hypertension.
    官方记录
  • iferanserin (S-MPEC)美国2010-12-13
    For use in pulmonary arterial hypertension.
    官方记录
  • Angiotensin-(1-7)美国2011-09-13
    Treatment of pulmonary arterial hypertension.
    官方记录
  • nitric oxide美国2011-12-28
    Treatment of pulmonary arterial hypertension
    官方记录
  • iloprost美国2012-04-06
    Treatment of pulmonary arterial hypertension
    官方记录
  • tiprelestat美国2012-12-28
    Treatment of pulmonary arterial hypertension
    官方记录
  • lisuride美国2013-01-17
    Treatment of pulmonary arterial hypertension
    官方记录
  • vasoactive intestinal peptide (VIP)-elastin-like peptide (ELP) fusion 美国2014-05-13
    Treatment of pulmonary arterial hypertension, WHO Group 1
    官方记录
  • ralinepag美国2014-08-28
    treatment of pulmonary arterial hypertension
    官方记录
  • (S)-3-((3-(1-((6-((3,4-dimethoxyphenyl)pryazin-2-yl)amino)ethyl)phenyl美国2014-11-17
    Treatment of pulmonary arterial hypertension
    官方记录
  • tacrolimus美国2015-03-16
    Treatment of pulmonary arterial hypertension.
    官方记录
  • bardoxolone美国2015-03-30
    Treatment of pulmonary arterial hypertension
    官方记录
  • rodatristat ethyl美国2015-10-06
    Treatment of pulmonary arterial hypertension (PAH).
    官方记录
  • ubenimex美国2015-11-19
    Treatment of pulmonary arterial hypertension.
    官方记录
  • treprostinil sodium solution enclosed within a pre-filled, pre-program美国2015-12-29
    Treatment of pulmonary arterial hypertension
    官方记录
  • 6-(4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-butoxy)-2H-benzo[b][1,4]o美国2016-11-09
    Treatment of pulmonary arterial hypertension (WHO Group 1)
    官方记录
  • patecibart美国2017-06-06
    Treatment of pulmonary arterial hypertension (PAH)
    官方记录
  • Active calcium sensing receptor antagonist derived from tetrahydropyra美国2017-06-13
    Treatment of pulmonary arterial hypertension
    官方记录
  • 2-{4-[(9R)-9-Hydroxy-2-(3-hydroxy-3-methylbutyloxy)-9-(trifluoromethyl美国2018-01-23
    Treatment of pulmonary arterial hypertension
    官方记录
  • N-(tert-butylcarbamoyl)-5-cyano-2-((4'-(difluoromethoxy)-[1,1'-bipheny美国2018-03-01
    Treatment of pulmonary arterial hypertension
    官方记录

另有 15 项未列出。

数据来自欧洲药品管理局(EMA)的药品与孤儿药资格公开导出表,以及美国 FDA 孤儿药资格数据库。两边口径不同:欧盟一侧取的是当前状态仍为「已授权」的药品;美国一侧记录的是「曾获批准」这一事实,FDA 的公开表不追踪药物此后是否退市(例如 Relyvrio 于 2024 年撤市,表中仍记为已获批)。请以官方记录页为准。

在中国开展的临床试验 90L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实,并与主治医生商量。

登记为可入组 19

  • 招募中NCT02061787
    the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension
    观察性 · 2010/09Chinese Pulmonary Vascular Disease Research Group
    中国研究中心 1 个:Beijing
  • 招募中NCT07184814
    Clinical Features and Prognosis of Takayasu's Arteritis With Pulmonary Arteries Involvement
    观察性 · 2016/01/01China-Japan Friendship Hospital
    中国研究中心 1 个:Beijing
  • 招募中NCT06954727
    China Pulmonary Vascular Disease Intervention Diagnosis and Management Study-right Heart Catheterization
    观察性 · 2018/01/01China-Japan Friendship Hospital
    中国研究中心 1 个:Beijing
  • 仅邀请入组NCT03683186
    A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
    III 期 · 干预性 · 2019/09/23United Therapeutics
    中国研究中心 5 个:Beijing、Changsha、Guangzhou、Shanghai
  • 招募中NCT05368467
    National Registry and Cohort Study of Pulmonary Vascular Disease
    观察性 · 2022/03/29Nanjing First Hospital, Nanjing Medical University
    中国研究中心 13 个:Beijing、Changsha、Chendu、Guangzhou、Nanjing、Shenyang 等 10 地
  • 招募中NCT05179876
    A Study Providing Treatment Access in Participants With Pulmonary Hypertension Completing a Parent Study and Having no Other Option
    III 期 · 干预性 · 2022/05/04Actelion
    中国研究中心 7 个:Beijing、Changsha、Nanjing、Qingdao、Shanghai、Xi'an
  • 招募中NCT05566002
    Artificial Intelligence-assisted Evaluation of Pulmonary HYpertension
    观察性 · 2022/06/01Chinese Pulmonary Vascular Disease Research Group
    中国研究中心 1 个:Beijing
  • 招募中NCT06605794
    FreeFlow Percutaneous Atrial Septal Shunt for IPAH
    不适用 · 干预性 · 2023/09/11Shanghai Zhongshan Hospital
    中国研究中心 1 个:Shanghai
  • 招募中NCT07604805
    Efficacy and Safety of Qishen Yiqi Dropping Pills in Patients With Severe Pulmonary Hypertension
    不适用 · 干预性 · 2023/10/25Guangdong Provincial People's Hospital
    中国研究中心 1 个:Guangzhou
  • 招募中NCT06528418
    Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath
    观察性 · 2024/06/30ChromX Health
    中国研究中心 1 个:Guangzhou
  • 招募中NCT07149935
    Continuous Effect Of Rehabilitation Training On Pulmonary Arterial Hypertension Patients
    不适用 · 干预性 · 2024/09/01RenJi Hospital
    中国研究中心 1 个:Shanghai
  • 招募中NCT06554301
    A Study on the Efficacy and Safety of Empagliflozin in the Treatment of Pulmonary Arterial Hypertension
    I 期 · 干预性 · 2024/10/20China National Center for Cardiovascular Diseases
    中国研究中心 1 个:Beijing
  • 招募中NCT06753981
    Efficacy and Safety of Triple-targeted Drug Therapy in Treatment-naive Patients With Non-low-risk PAH: A Real-world, Multicenter Study
    观察性 · 2024/12/10Qianfoshan Hospital
    中国研究中心 1 个:Jinan
  • 招募中NCT07039604
    Real-World Study of PADN for the Treatment of PAH
    观察性 · 2025/03/19Pulnovo Medical (Wuxi) Co., Ltd.
    中国研究中心 1 个:Nanjing
  • 尚未开始招募NCT06922916
    Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
    观察性 · 2025/04/22Zhejiang University
    中国研究中心 1 个:Hangzhou
  • 招募中NCT06968962
    Comparison of Sequential to Initial Combination Therapy in PAH
    不适用 · 干预性 · 2025/05/14Second Affiliated Hospital, Zhejiang University, School of Medicine
    中国研究中心 1 个:Hangzhou
  • 招募中NCT07073820
    A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489
    II 期 · 干预性 · 2025/11/10Pfizer
    中国研究中心 4 个:Changsha、Guangzhou、Nanjing、Shanghai
  • 招募中NCT07593027
    A Phase Ⅰb/Ⅱa Clinical Study of IMC-003 Injection for the Treatment of Pulmonary Arterial Hypertension Receiving Background Therapy.
    I 期、II 期 · 干预性 · 2026/04/30ImmuneCare Biopharmaceuticals (Shanghai) Co., Ltd.
    中国研究中心 26 个:Beijing、Changsha、Chengdu、Fuzhou、Guangzhou、Guiyang 等 19 地
  • 尚未开始招募NCT07667829
    Vasopressor Agents in Pulmonary Hypertension Crisis
    不适用 · 干预性 · 2026/06China National Center for Cardiovascular Diseases
    中国研究中心 3 个:Beijing、Guangzhou、Wuhan
其他状态的试验(71 项)
  • 已完成NCT00257413
    Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension
    不适用 · 干预性Zhejiang University
    中国研究中心 1 个:Hangzhou
  • 已完成NCT00091715
    Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
    III 期 · 干预性 · 2004/04Actelion
    中国研究中心 1 个:Hong Kong
  • 已完成NCT00641836
    Safety and Feasibility of Autologous Endothelial Progenitor Cells Transplantation in Patients With Idiopathic Pulmonary Arterial Hypertension
    不适用 · 干预性 · 2005/07Zhejiang University
    中国研究中心 1 个:Hangzhou
  • 已完成NCT00240656
    Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension
    I 期 · 干预性 · 2005/10Hebei Medical University
    中国研究中心 1 个:Shijiazhuang
  • 状态未知NCT00372346
    Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension
    不适用 · 干预性 · 2006/06Zhejiang University
    中国研究中心 1 个:Hangzhou
  • 已完成NCT00325403
    FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)
    III 期 · 干预性 · 2006/10United Therapeutics
    中国研究中心 3 个:Beijing、Shanghai
  • 已完成NCT01027949
    An Open-Label Extension Trial of UT-15C Sustained-release (SR) in Subjects With Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2007/01/16United Therapeutics
    中国研究中心 3 个:Beijing、Shanghai
  • 已完成NCT00615823
    Atorvastatin in Pulmonary Hypertension
    II 期 · 干预性 · 2007/02Chinese Academy of Medical Sciences, Fuwai Hospital
    中国研究中心 1 个:Beijing
  • 已终止NCT00430716
    To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension.
    IV 期 · 干预性 · 2008/04/08Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
    中国研究中心 2 个:Beijing、Shanghai
  • 已完成NCT00660179
    Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2008/05Actelion
    中国研究中心 9 个:Beijing、Guangzhou、Nanjing、Shanghai
  • 已完成NCT00718952
    The Efficacy and Safety of Vardenafil in the Treatment of Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2008/07Tongji University
    中国研究中心 9 个:Beijing、Changsha、Harbin、Shanghai、Shenyang、Xi’an
  • 已终止NCT00706082
    Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc)
    观察性 · 2008/10Actelion
    中国研究中心 1 个:Beijing
  • 已完成NCT00667823
    Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2008/10/17Actelion
    中国研究中心 8 个:Beijing、Guangzhou、Nanjing、Shanghai
  • 已终止NCT00795639
    Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil (SR-PAAS)
    III 期 · 干预性 · 2008/12Pfizer
    中国研究中心 4 个:Beijing、Changsha、Shanghai、Xi’an
  • 已完成NCT00810693
    A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With Pulmonary Arterial Hypertension (PAH)
    III 期 · 干预性 · 2008/12/17Bayer
    中国研究中心 3 个:Beijing、Guangzhou、Shanghai
  • 已完成NCT00863681
    BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2009/03/12Bayer
    中国研究中心 3 个:Beijing、Guangzhou、Shanghai
  • 已终止NCT00796666
    Study Looking at Combination Therapy (Sitaxsentan+Sildenafil) Vs. Monotherapy (Sitaxsentan Alone) SR-PAAS -Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil
    III 期 · 干预性 · 2009/05Pfizer
    中国研究中心 3 个:Beijing、Changsha、Shanghai
  • 状态未知NCT01417338
    Registry for Pulmonary Hypertension in China
    观察性 · 2009/08Chinese Academy of Medical Sciences, Fuwai Hospital
    中国研究中心 1 个:Beijing
  • 已完成NCT01106014
    Selexipag (ACT-293987) in Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2009/12/01Actelion
    中国研究中心 7 个:Beijing、Guangzhou、Shanghai
  • 已完成NCT01112306
    ACT-293987 in Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2010/07/07Actelion
    中国研究中心 3 个:Beijing、Guangzhou、Shanghai
  • 已完成NCT01338415
    FUTURE 3 Study Extension
    III 期 · 干预性 · 2011/03/08Actelion
    中国研究中心 2 个:Beijing、Shanghai
  • 已完成NCT01447628
    IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients
    II 期 · 干预性 · 2011/03/29Imperial College London
    中国研究中心 1 个:Beijing
  • 状态未知NCT03567668
    Surgical Valvuloplasty for Congenital Mitral Insufficiency
    观察性 · 2012/01/01Hong Liu
    中国研究中心 1 个:Tianjin
  • 已完成NCT01560624
    Phase III Clinical Worsening Study of UT-15C in Subjects With PAH Receiving Background Oral Monotherapy
    III 期 · 干预性 · 2012/06/26United Therapeutics
    中国研究中心 16 个:Beijing、Changsha、Chengdu、Guangzhou、Nanchang、Nanjing 等 10 地
  • 状态未知NCT01712997
    Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients
    III 期 · 干预性 · 2012/09Air Force Military Medical University, China
    中国研究中心 2 个:Xi'an
  • 已完成NCT01808313
    Efficacy Study of Ambrisentan in Chinese Patients With Pulmonary Arterial Hypertension (PAH)
    III 期 · 干预性 · 2012/12/01GlaxoSmithKline
    中国研究中心 8 个:Beijing、Changchun、Harbin、Hunan、Jinan、Shanghai 等 8 地
  • 已完成NCT07164157
    The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension
    观察性 · 2013/01/01Wei Huang
    中国研究中心 1 个:Chongqing
  • 状态未知NCT01637675
    Efficacy and Safety Study of Sodium Tanshinone IIA Sulfonate on Pulmonary Hypertension
    II 期、III 期 · 干预性 · 2013/05The First Affiliated Hospital of Guangzhou Medical University
    中国研究中心 1 个:Guangzhou
  • 已完成NCT01743001
    Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome
    III 期 · 干预性 · 2013/05/21Actelion
    中国研究中心 6 个:Beijing、Guangzhou、Shanghai、Shenyang、Wuhan
  • 已终止NCT01739400
    Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome
    III 期 · 干预性 · 2013/09/10Actelion
    中国研究中心 6 个:Beijing、Guangzhou、Shanghai、Shenyang、Wuhan
  • 已完成NCT01560637
    An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension
    III 期 · 干预性 · 2013/09/11United Therapeutics
    中国研究中心 16 个:Beijing、Changsha、Chengdu、Guangzhou、Nanchang、Nanjing 等 10 地
  • 状态未知NCT02023450
    Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension
    早期 I 期 · 干预性 · 2013/12The Third Xiangya Hospital of Central South University
    中国研究中心 1 个:Changsha
  • 已完成NCT02267200
    The Screening and Analysis of Plasma Biomarkers in Irreversible PAH-CHD
    观察性 · 2014/10Shanghai Jiao Tong University School of Medicine
    中国研究中心 1 个:Shanghai
  • 已终止NCT02284737
    A Study to Investigate the Efficacy of PADN to Improved Functional Capacity and Hemodynamics in Patients With PAH
    IV 期 · 干预性 · 2014/11/28Nanjing First Hospital, Nanjing Medical University
    中国研究中心 1 个:Nanjing
  • 已撤回NCT02893995
    Safety, Tolerability, Pharmacokinetics and Efficacy of Two Different Rates of Subcutanous Remodulin® Dose Titration in Pulmonary Arterial Hypertension
    IV 期 · 干预性 · 2017/02United Therapeutics
    中国研究中心 10 个:Beijing、Changsha、Guangzhou、Shanghai、Wuhan
  • 已撤回NCT02882126
    An Open Label Extension Study to Evaluate the Safety of Continued Therapy of Subcutanous Remodulin® in Pulmonary Arterial Hypertension
    IV 期 · 干预性 · 2017/06United Therapeutics
    中国研究中心 10 个:Beijing、Changsha、Guangzhou、Shanghai、Wuhan
  • 已完成NCT02932410
    A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)
    III 期 · 干预性 · 2017/10/24Actelion
    中国研究中心 4 个:Beijing、Qingdao、Shanghai
  • 状态未知NCT04053296
    Long-term Outcomes of Pregnant Women With PAH
    观察性 · 2017/11/01RenJi Hospital
    中国研究中心 1 个:Shanghai
  • 状态未知NCT03954405
    Multi-marker Approach for Risk Assessment in PAH
    观察性 · 2017/11/01Wuhan Asia Heart Hospital
    中国研究中心 1 个:Wuhan
  • 已完成NCT03282266
    Safety and Efficacy of Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension
    不适用 · 干预性 · 2018/01/18Nanjing First Hospital, Nanjing Medical University
    中国研究中心 1 个:Nanjing

另有 31 项未列出。

中国境外的在招试验 132L2

这些试验在中国没有研究中心,通常无法直接报名——入组一般要求在当地居住并接受随访。列在这里是因为它另有用处:看清楚全世界正在试哪些药、做到了哪一期、由谁在做。把药名和 NCT 编号记下来去问主治医生,或据此进一步查该药是否已在境外获批、是否有拓展性用药(expanded access)通道。

美国45法国14西班牙10巴西10英国10德国8加拿大7澳大利亚7意大利7比利时6波兰6以色列4拉脱维亚4韩国4另有 29 个国家/地区

CT.gov 报告命中 132 项,此处取回并展示最近的 15 项。

  • 尚未开始招募NCT07172334
    What is the Role of the Exposome in Pulmonary Hypertension
    观察性 · 2027/01Poitiers University Hospital
    法国
  • 尚未开始招募NCT07600723
    A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037)
    IV 期 · 干预性 · 2026/11/04Merck Sharp & Dohme LLC
  • 尚未开始招募NCT07632898
    Open-Label Study of IKT-001 in Pulmonary Arterial Hypertension (PAH)
    III 期 · 干预性 · 2026/10/23Inhibikase Therapeutics
  • 尚未开始招募NCT07737522
    Myocardial Metabolic Flux in Pulmonary Arterial Hypertension
    II 期 · 干预性 · 2026/10/01Imperial College London
  • 尚未开始招募NCT07700303
    Withdrawal of Prostacyclin Pathway Therapy in Patients With Pulmonary Arterial Hypertension Receiving Sotatercept (WATERLOO)
    不适用 · 干预性 · 2026/09/30University of Alberta
    加拿大
  • 尚未开始招募NCT07761572
    CS1 Added to Standard of Care Therapy for Pulmonary Arterial Hypertension
    II 期 · 干预性 · 2026/09/15Cereno Scientific AB
  • 尚未开始招募NCT07717060
    Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis
    不适用 · 干预性 · 2026/09/01Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  • 尚未开始招募NCT06176118
    Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension
    II 期 · 干预性 · 2026/09/01Vanderbilt University Medical Center
  • 尚未开始招募NCT07751120
    Microbiota Transplant With Antibiotic Preconditioning and Fiber Supplementation in PAH.
    I 期 · 干预性 · 2026/09/01University of Minnesota
    美国
  • 尚未开始招募NCT07759804
    A Study of Inhaled Treprostinil (LIQ861) in Adults With Pulmonary Arterial Hypertension Transitioning From Oral Selexipag
    IV 期 · 干预性 · 2026/09Liquidia Technologies, Inc.
    美国
  • 尚未开始招募NCT07646860
    A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)
    II 期 · 干预性 · 2026/08/31Merck Sharp & Dohme LLC
  • 招募中NCT07613099
    Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
    III 期 · 干预性 · 2026/08/23National Heart, Lung, and Blood Institute (NHLBI)
    美国
  • 招募中NCT07143448
    A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults
    I 期、II 期 · 干预性 · 2026/0835Pharma Inc
    西班牙、美国
  • 招募中NCT07713914
    Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial Hypertension
    IV 期 · 干预性 · 2026/07/22University of Sao Paulo General Hospital
    巴西
  • 尚未开始招募NCT07357974
    Impact of Sotatercept on Pulmonary Artery and Right Ventricle Remodeling Imaging Assessed With 68Ga-FAPI PET/CT in Patients With PAH
    I 期、II 期 · 干预性 · 2026/07/15University Hospital, Brest
    法国

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本页数据来源

  • 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
  • 中文病名:Orphanet 中文包,冻结于 2020-06-01
  • 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)