上皮样肉瘤

定义

上皮样肉瘤是一种罕见的软组织肿瘤，其特点是局部复发率高，局部淋巴结受累和远处转移。常累及手指、手、前臂、小腿或足部皮下软组织，很少累及身体其他部位。

基本事实

遗传方式

不适用

发病年龄

青少年期、成年期、儿童期

患病率

<1 / 1 000 000（Europe）

近两年的全球研究 664L2

2024/08 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-08综述
  Pediatric sarcomas: challenges and opportunities
  Genes & development · DOI · Europe PMC
• 2026-07病例报告
  Endovascular Management of Interlobolar Bronchopulmonary Arterial Fistula After Bronchial Stent Removal
  JACC. Case reports · DOI · Europe PMC
• 2026-07病例报告
  Epithelioid Sarcoma: A Hand Surgeon's Dilemma
  Plastic and reconstructive surgery. Global open · DOI · Europe PMC
• 2026-06
  Myoepithelioma-like tumor of the vulvar region shows a quiet genome and heterogeneous detectable mechanisms of SMARCB1 inactivation: Integrated analysis of two cases and review of the literature
  Annals of diagnostic pathology · DOI · Europe PMC
• 2026-06病例报告
  SMARCB1-Deficient Malignant Orbital Neoplasm with Features Overlapping Myxoid Epithelioid Sarcoma: A Diagnostic Challenge
  Head and neck pathology · DOI · Europe PMC
• 2026-06
  In Response to Interesting Image Titled "99mTc-FAPI-46 Scintigraphy and Radioligand Therapy With 177Lu-FAPI-2286 in Locally Advanced Epithelioid Sarcoma"
  Clinical nuclear medicine · DOI · Europe PMC
• 2026-06
  Utidelone in patients with advanced soft tissue sarcoma refractory to anthracycline and antiangiogenic therapy (UTISARC): a single-arm phase II study
  BMC medicine · DOI · Europe PMC
• 2026-06综述开放获取
  SMARCA4-Directed Treatment in Oncology Clinical Trials: A Review
  Journal of immunotherapy and precision oncology · DOI · Europe PMC
• 2026-06综述开放获取
  The Role of EZH2 ın Malıgnant Pleural Mesothelıoma and Beyond: Current Practıce and Future Perspectıves
  Current oncology reports · DOI · Europe PMC
• 2026-06开放获取
  B7-H3 membranous expression correlates with histological grading in a two-center cohort of 133 pre-treatment bone and soft tissue sarcoma samples
  BMC cancer · DOI · Europe PMC
• 2026-06病例报告开放获取
  Epithelioid fibrous histiocytoma of eyelid in children: A case report
  Experimental and therapeutic medicine · DOI · Europe PMC
• 2026-06开放获取
  Efficacy and Tolerability of Pazopanib in Elderly Patients with Advanced Soft Tissue Sarcoma: A Multicentre Real-World Study from Turkey
  Journal of clinical medicine
• 2026-06开放获取
  Concomitant Medication Effects on Immunotherapy Outcomes in Sarcoma: A Pooled Post Hoc Analysis of Seven Phase II Trials
  Cancer medicine · DOI · Europe PMC
• 2026-06综述开放获取
  Clinical Implications of Polyploid Giant Cancer Cells in Solid Tumors: Biology, Diagnosis, and Therapeutic Considerations
  Cancers · 被引 1 · DOI · Europe PMC
• 2026-06开放获取
  Systemic Treatment of Advanced Chordoma With Molecular Targeted Therapies: A Large Multicentre European Retrospective Case Series
  Cancer reports (Hoboken, N.J.) · DOI · Europe PMC
• 2026-06系统综述开放获取
  Assessing Treatment Response in Soft Tissue Sarcoma Using Dynamic Contrast-Enhanced MRI: A Systematic Review
  Korean journal of radiology · DOI · Europe PMC
• 2026-05开放获取
  FusionTarget: Computational framework for drug repurposing against modeled fusion protein structures from genomic breakpoints
  iScience · DOI · Europe PMC
• 2026-05综述病例报告开放获取
  Epithelioid Sarcoma of the Oral Cavity: A Multi-institutional Clinicopathologic and Immunophenotypic Characterization of Five Cases and Comprehensive Literature Review
  Head and neck pathology · DOI · Europe PMC
• 2026-05开放获取
  Leveraging Dog Models to Uncover Human Cancer Insights
  Research square
• 2026-05开放获取
  Swelling of the Left Upper Limb with Red Papules, Necrosis and Crusting: A Quiz
  Acta dermato-venereologica · DOI · Europe PMC

在中国开展的临床试验 4L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 3

• 招募中NCT04390737
  Evaluate the Safety and Clinical Activity of HH2853
  I 期、II 期 · 干预性 · 2020/09/08Haihe Biopharma Co., Ltd.
  中国研究中心 18 个：Beijing、Changsha、Chengdu、Guangzhou、Hangzhou、Hefei 等 15 地
• 招募中NCT06277154
  MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma
  II 期 · 干预性 · 2024/02/21HRYZ Biotech Co.
  中国研究中心 1 个：Guangzhou
• 招募中NCT06683846
  Ivonescimab in the Treatment of Multiple Advanced Tumors
  II 期 · 干预性 · 2024/11/20Fudan University
  中国研究中心 1 个：Shanghai

中国境外的在招试验 15L2

CT.gov 报告命中 15 项，此处取回并展示最近的 12 项。

• 尚未开始招募NCT07734116
  A Study of ONO-4538HSC in Pediatric Patients With Malignant Solid Tumors and in Patients With Epithelioid Sarcoma.
  I 期、II 期 · 干预性 · 2026/08/15Ono Pharmaceutical Co., Ltd.
  日本
• 招募中NCT07467772
  Ph 2 Elacestrant in ER Positive Uterine Sarcomas
  II 期 · 干预性 · 2026/03/25Dana-Farber Cancer Institute
  美国
• 招募中NCT06625190
  Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
  I 期、II 期 · 干预性 · 2026/02/11University of Florida
  美国
• 招募中NCT07089992
  A Study of Pembrolizumab in People With Ultra-Rare Sarcomas
  II 期 · 干预性 · 2025/12/04Memorial Sloan Kettering Cancer Center
  美国
• 招募中NCT06715579
  Cardiac Angiosarcoma International Registry
  观察性 · 2025/05/01Immune Oncology Research Institute
  Armenia
• 招募中NCT07675967
  Clonal Hematopoiesis Chemotherapy and Radiation Effects Study
  观察性 · 2025/04/04Dana-Farber Cancer Institute
  美国
• 招募中NCT06239272
  NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
  I 期、II 期 · 干预性 · 2024/03/27St. Jude Children's Research Hospital
  美国
• 招募中NCT06408441
  The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
  观察性 · 2023/12/01Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
  奥地利、丹麦、法国、德国、意大利、波兰、葡萄牙、西班牙 等 10 国
• 招募中NCT03967834
  Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group
  不适用 · 干预性 · 2021/04/26Institut Claudius Regaud
  法国
• 招募中NCT04300257
  Swiss Sarcoma Network: Prediction Model for Patient Selection in Sarcoma Care
  观察性 · 2019/10/19Kantonsspital Winterthur KSW
  瑞士
• 招募中NCT03099681
  An Observational Study on Epithelioid Sarcoma
  观察性 · 2017/08/22Italian Sarcoma Group
  意大利
• 可获取（拓展性用药）NCT07502716
  Compassionate Use of Ubamatamab
  拓展性用药Regeneron Pharmaceuticals

外部标识与链接