上皮样肉瘤

定义

上皮样肉瘤是一种罕见的软组织肿瘤，其特点是局部复发率高，局部淋巴结受累和远处转移。常累及手指、手、前臂、小腿或足部皮下软组织，很少累及身体其他部位。

基本事实

遗传方式

不适用

发病年龄

青少年期、成年期、儿童期

患病率

<1 / 1 000 000（Europe）

近两年的全球研究 743L2

2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-09开放获取
  SMARCB1 (INI1)-Deficient Undifferentiated Rectal Carcinoma Mimicking Sarcoma: A Case Report and Literature Review
  Clinical case reports · DOI · Europe PMC
• 2026-09开放获取
  Clinicopathological Prognostic Factors After Pulmonary Metastasectomy for Bone and Soft-Tissue Sarcoma: A Single-Centre Retrospective-Prospective Cohort Study
  Cancers · DOI · Europe PMC
• 2026-09综述开放获取
  Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities
  Signal transduction and targeted therapy · DOI · Europe PMC
• 2026-09综述开放获取
  Next-Generation Sequencing in Translational Sarcoma Research: Biological Insights and Emerging Directions
  Current oncology reports · DOI · Europe PMC
• 2026-09综述开放获取
  The Epigenetic Aging-Cancer Continuum: Biomarkers, Metabolism, and Therapy
  Genes · DOI · Europe PMC
• 2026-09开放获取
  Targeting the DNA-repair chromatin-modifier protein SMYD3 as a novel epigenetics-based therapy for gastric cancer
  Journal of experimental & clinical cancer research : CR · DOI · Europe PMC
• 2026-09
  Epithelioid sarcoma: A retrospective review from a single centre tertiary orthopaedic sarcoma unit
  European journal of surgical oncology : the journal of the European So · DOI · Europe PMC
• 2026-09
  Epithelioid Enigma: Proximal-Type Epithelioid Sarcoma in Cyst Fluid Cytology
  Diagnostic cytopathology · DOI · Europe PMC
• 2026-09
  Diagnostic Superiority of 68Ga-FAPI PET/CT Over 18F-FDG in Restaging of Advanced Epithelioid Sarcoma
  Clinical nuclear medicine · DOI · Europe PMC
• 2026-09病例报告开放获取
  Malignant rhabdoid tumor of the kidney in a 7-month-old infant: A rare case report with molecular confirmation of SMARCB1 deletion
  Urology case reports
• 2026-09综述开放获取
  Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies
  Experimental hematology & oncology · DOI · Europe PMC
• 2026-09开放获取
  LncRNA DLGAP1-AS2 promotes ESCC progression and indicates unfavorable prognosis via the miR-101-3p/EZH2 axis
  Discover oncology · DOI · Europe PMC
• 2026-09综述开放获取
  Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability
  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene th · DOI · Europe PMC
• 2026-09开放获取
  Real-world experience with ipilimumab in combination with nivolumab in advanced sarcoma: a retrospective analysis including ultra-rare sarcomas
  The oncologist · DOI · Europe PMC
• 2026-09病例报告开放获取
  Metastatic Leiomyosarcoma Involving Bone and Kidney in an Adult Budgerigar (Melopsittacus undulatus)
  Veterinary medicine and science · DOI · Europe PMC
• 2026-09随机对照试验开放获取
  A Randomized Phase II Study of Combination Atezolizumab and Varlilumab (CDX-1127) with or without Cobimetinib in Previously Treated Unresectable Biliary Tract Cancer
  Clinical cancer research : an official journal of the American Associa · DOI · Europe PMC
• 2026-08综述开放获取
  Histone modifications: mechanisms, metabolic regulation, and therapeutic targeting in cancer
  Precision clinical medicine · DOI · Europe PMC
• 2026-08综述开放获取
  Enhancer of Zeste Homolog 2 (EZH2): From Glioblastoma Biology to Potential Epigenetic Therapy
  International journal of molecular sciences · DOI · Europe PMC
• 2026-08开放获取
  Immune-epigenetic convergence in biomaterial-guided tissue regeneration
  Materials today. Bio · DOI · Europe PMC
• 2026-08病例报告开放获取
  Paratesticular epithelioid sarcoma in a pediatric patient
  Urology case reports · DOI · Europe PMC

在中国开展的临床试验 4L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 3

• 招募中NCT04390737
  Evaluate the Safety and Clinical Activity of HH2853
  I 期、II 期 · 干预性 · 2020/09/08Haihe Biopharma Co., Ltd.
  中国研究中心 18 个：Beijing、Changsha、Chengdu、Guangzhou、Hangzhou、Hefei 等 15 地
• 招募中NCT06277154
  MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma
  II 期 · 干预性 · 2024/02/21HRYZ Biotech Co.
  中国研究中心 1 个：Guangzhou
• 招募中NCT06683846
  Ivonescimab in the Treatment of Multiple Advanced Tumors
  II 期 · 干预性 · 2024/11/20Fudan University
  中国研究中心 1 个：Shanghai

中国境外的在招试验 15L2

CT.gov 报告命中 15 项，此处取回并展示最近的 12 项。

• 招募中NCT07734116
  A Study of ONO-4538HSC in Pediatric Patients With Malignant Solid Tumors and in Patients With Epithelioid Sarcoma.
  I 期、II 期 · 干预性 · 2026/08/18Ono Pharmaceutical Co., Ltd.
  日本
• 招募中NCT07467772
  Ph 2 Elacestrant in ER Positive Uterine Sarcomas
  II 期 · 干预性 · 2026/03/25Dana-Farber Cancer Institute
  美国
• 招募中NCT06625190
  Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
  I 期、II 期 · 干预性 · 2026/02/11University of Florida
  美国
• 招募中NCT07089992
  A Study of Pembrolizumab in People With Ultra-Rare Sarcomas
  II 期 · 干预性 · 2025/12/04Memorial Sloan Kettering Cancer Center
  美国
• 招募中NCT06715579
  Cardiac Angiosarcoma International Registry
  观察性 · 2025/05/01Immune Oncology Research Institute
  Armenia
• 招募中NCT07675967
  Clonal Hematopoiesis Chemotherapy and Radiation Effects Study
  观察性 · 2025/04/04Dana-Farber Cancer Institute
  美国
• 招募中NCT06239272
  NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
  I 期、II 期 · 干预性 · 2024/03/27St. Jude Children's Research Hospital
  美国
• 招募中NCT06408441
  The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
  观察性 · 2023/12/01Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
  奥地利、丹麦、法国、德国、意大利、波兰、葡萄牙、西班牙 等 10 国
• 招募中NCT03967834
  Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group
  不适用 · 干预性 · 2021/04/26Institut Claudius Regaud
  法国
• 招募中NCT04300257
  Swiss Sarcoma Network: Prediction Model for Patient Selection in Sarcoma Care
  观察性 · 2019/10/19Kantonsspital Winterthur KSW
  瑞士
• 招募中NCT03099681
  An Observational Study on Epithelioid Sarcoma
  观察性 · 2017/08/22Italian Sarcoma Group
  意大利
• 可获取（拓展性用药）NCT07502716
  Compassionate Use of Ubamatamab
  拓展性用药Regeneron Pharmaceuticals

外部标识与链接