胎儿巨细胞病毒综合征
Fetal cytomegalovirus syndrome
ORPHA:294疾病
定义 英文原文（暂无中文）
A fetopathy that is likely to occur when a cytomegalovirus (CMV) infected pregnant woman transmits the virus in utero. Children born with congenital CMV infection may present with hepatomegaly, splenomegaly, jaundice, pneumonitis, fetal growth retardation, petechiae, purpura, and thrombocytopenia. Congenital CMV infection can equally result in major neurological sequelae, including microcephaly, intracranial calcifications, sensorineural hearing loss, chorioretinitis, intellectual and motor disabilities, and seizure disorders. CMV disease sequelae caused by a primary infection are usually more severe than those caused by the reactivation of a latent infection.
别名
母婴传播巨细胞病毒综合征
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 产前、新生儿期
- 患病率
- 1-5 / 10 000（Europe）
临床表型 20
常见 79–30%10
- 凝血异常 HP:0001928
- 贫血 HP:0001903
- 脉络膜视网膜炎 HP:0012424
- 高结合胆红素血症 HP:0002908
- 循环肝转氨酶水平升高 HP:0002910
- 肝脏肿大 HP:0002240
- 智力障碍 HP:0001249
- 感音神经性听力受损 HP:0000407
- 脾肿大 HP:0001744
- 血小板减少症 HP:0001873
偶见 29–5%10
- 脑钙化 HP:0002514
- 肝炎 HP:0012115
- 胎儿宫内发育迟缓 HP:0001511
- 黄疸 HP:0000952
- 小头畸形 HP:0000252
- 视神经萎缩 HP:0000648
- 瘀点 HP:0000967
- 视网膜出血 HP:0000573
- 癫痫发作 HP:0001250
- 巨脑室 HP:0002119
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）