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脊髓灰质炎后综合征

Postpoliomyelitis syndrome

ORPHA:2942疾病

定义 英文原文（暂无中文）

Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis, 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.

别名

脊髓灰质炎后综合征

基本事实

遗传方式
不适用
发病年龄
青少年期、成年期、老年期

临床表型 17

极常见 99–80%2

  • 肌无力 HP:0001324
  • 疼痛 HP:0012531

常见 79–30%6

  • 精神功能异常 HP:0011446
  • 关节疼痛 HP:0002829
  • 爬楼梯困难 HP:0003551
  • 疲乏 HP:0012378
  • 过度睡眠 HP:0100786
  • 肌痛 HP:0003326

偶见 29–5%8

  • 关节形态异常 HP:0001367
  • 构音障碍 HP:0001260
  • 吞咽困难 HP:0002015
  • 肌束震颤 HP:0002380
  • 肌肉痉挛 HP:0003394
  • 呼吸功能不全 HP:0002093
  • 骨骼肌萎缩 HP:0003202
  • 睡眠异常 HP:0002360

罕见 <4–1%1

  • 通气不足 HP:0002791

外部标识与链接

OrphanetMONDO:0017416GARD:4454ICD-10 G14ICD-11 8B62ClinicalTrials.gov 检索

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本页数据来源

  • 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
  • 中文病名：Orphanet 中文包，冻结于 2020-06-01
  • 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）