秋水仙碱中毒
Colchicine poisoning
ORPHA:31824疾病
定义 英文原文(暂无中文)
Colchicine poisoning is a potentially life-threatening poisoning, due to ingestion of the drug or consumption of the plant Colchicum autumnale, that usually begins with gastrointestinal symptoms (e.g. abdominal pain, nausea, vomiting, and diarrhea, that cause severe dehydration) and an initial leukocytosis leading to marrow failure (24 hours after ingestion), followed by potentially fatal multi-organ failure with mental status change, oliguric renal failure, disseminated intravascular coagulation, electrolyte imbalance, acid-base disturbance, cardiac failure/arrest and shock within 1-3 days.
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 各年龄段
- 患病率
- 1-9 / 1 000 000(Europe)
临床表型 29
极常见 99–80%7
- 脱水 HP:0001944
- 低血压 HP:0002615
- 白细胞增多症 HP:0001974
- 代谢性酸中毒 HP:0001942
- 恶心 HP:0002018
- 呼吸窘迫 HP:0002098
- 呕吐 HP:0002013
常见 79–30%21
- 离子稳态平衡异常 HP:0003111
- 酸碱平衡异常 HP:0004360
- 血液和造血组织异常 HP:0001871
- 急性脑病 HP:0006846
- 心律失常 HP:0011675
- 心源性休克 HP:0030149
- 心跳呼吸骤停 HP:0006543
- 充血性心力衰竭 HP:0001635
- 腹泻 HP:0002014
- 弥漫性血管内凝血 HP:0005521
- 低钙血症 HP:0002901
- 低钾血症 HP:0002900
- 低镁血症 HP:0002917
- 低钠血症 HP:0002902
- 低磷血症 HP:0002148
- 血容量不足 HP:0011106
- 乳酸酸中毒 HP:0003128
- 心肌炎 HP:0012819
- 少尿症 HP:0100520
- 意识下降 HP:0004372
- 肾功能不全 HP:0000083
偶见 29–5%1
- 脱发 HP:0001596
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
- 中文病名:Orphanet 中文包,冻结于 2020-06-01
- 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)