Takayasu大动脉炎

定义 英文原文（暂无中文）

A rare predominantly large-vessel vasculitis that is characterized by affected aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.

基本事实

遗传方式

不适用

发病年龄

青少年期、成年期

患病率

<1 / 1 000 000（Europe）

相关基因 3

临床表型 54

近两年的全球研究 1,231L2

2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-10
  [Expert consensus on the operational protocol for radionuclide pulmonary ventilation/perfusion scintigraphy of pulmonary thromboembolism]
  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chine · DOI · Europe PMC
• 2026-09
  Comparative Effectiveness of Tocilizumab and Tumor Necrosis Factor Inhibitors in Takayasu Arteritis: Age-Related Differences in Treatment Response
  Arthritis care & research · DOI · Europe PMC
• 2026-09综述
  Takayasu Arteritis Presenting With Upper Extremity Ischemia Treated by Carotid-Humeral Bypass: A Case-Based Review
  The American surgeon · DOI · Europe PMC
• 2026-09
  Increased mortality rate in patients with Takayasu arteritis is largely driven by early disease activity and damage: analysis of two cohorts
  Rheumatology (Oxford, England) · DOI · Europe PMC
• 2026-09病例报告
  Takayasu arteritis manifesting as pyrexia of unknown origin and massive splenomegaly
  BMJ case reports · DOI · Europe PMC
• 2026-09开放获取
  Giant abdominal hematoma from injection into an insulin ball during dual antithrombotic and corticosteroid therapy
  Journal of diabetes investigation · DOI · Europe PMC
• 2026-09综述
  The MHC-I-opathy architecture: immunogenetic and biomechanical determinants of disease expression
  Zeitschrift fur Rheumatologie · DOI · Europe PMC
• 2026-09
  Reversing the Reverse: Nitrate-Enhanced Tc-99m MIBI MPS Unmasking Microvascular Dysfunction in Takayasu Arteritis
  Clinical nuclear medicine · DOI · Europe PMC
• 2026-09开放获取
  Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study
  European radiology experimental · DOI · Europe PMC
• 2026-09病例报告开放获取
  Unusual blue discolouration of the ascending aorta in a patient with Churg-Strauss syndrome undergoing surgical aortic valve replacement: a case report
  Journal of surgical case reports · DOI · Europe PMC
• 2026-09开放获取
  Proceedings of the 33rd European Paediatric Rheumatology Congress
  Pediatric rheumatology online journal · DOI · Europe PMC
• 2026-09综述开放获取
  How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis
  Paediatric drugs · DOI · Europe PMC
• 2026-09开放获取
  Takayasu Arteritis in a G6PD Deficient Female Patient With Recurrent Axillary Artery Stenosis: A Case Report
  Clinical case reports · DOI · Europe PMC
• 2026-09综述开放获取
  Interface between inborn errors of immunity and rheumatological disorders in children: A pediatrician's conundrum
  World journal of clinical pediatrics · DOI · Europe PMC
• 2026-09
  Collateral vessels supplying blood to the brain and the entire upper body in a patient with Takayasu arteritis
  Journal of vascular surgery · DOI · Europe PMC
• 2026-09
  Bilateral Pulmonary Arterial Involvement in Takayasu Arteritis
  Balkan medical journal · DOI · Europe PMC
• 2026-09开放获取
  Cardiovascular Risks in Autoimmune and Inflammatory Diseases
  Journal of clinical medicine · DOI · Europe PMC
• 2026-09开放获取
  Takayasu arteritis presenting with dysphagia and morning stiffness: a diagnostic challenge in a middle-aged woman
  The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian · DOI · Europe PMC
• 2026-09综述
  Undiagnosed Thoracic Aortic Aneurysms: Prevalence, Risk Factors, Screening Modalities
  Deutsches Arzteblatt international · DOI · Europe PMC
• 2026-09
  Time Passes, The Valve Migrates: Silent Prosthetic Valve Migration in Takayasu Arteritis
  JACC. Case reports · DOI · Europe PMC

境外已获批用于本病的药物 0L2

欧盟与美国均未检索到已获批用于本病的药物。

数据来自欧洲药品管理局（EMA）的药品与罕见病用药资格公开导出表，以及美国 FDA 的罕见病用药资格数据库（Orphan Drug Product Designation Database）。两边口径不同：欧盟一侧取的是当前状态仍为「已授权」的药品；美国一侧记录的是「曾获批准」这一事实，FDA 的公开表不追踪药物此后是否退市（例如 Relyvrio 于 2024 年撤市，表中仍记为已获批）。请以官方记录页为准。

在中国开展的临床试验 25L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 10

• 招募中NCT05388682
  Treatment of Patients With Takayasu Arteritis Complicated With Pulmonary Artery Involvement
  观察性 · 2014/01/19Chinese Pulmonary Vascular Disease Research Group
  中国研究中心 1 个：Beijing
• 招募中NCT03372980
  A Registry Study on Biomarkers of Takayasu's Arteritis (ARSBTA)
  观察性 · 2016/01Beijing Institute of Heart, Lung and Blood Vessel Diseases
  中国研究中心 1 个：Beijing
• 招募中NCT07184814
  Clinical Features and Prognosis of Takayasu's Arteritis With Pulmonary Arteries Involvement
  观察性 · 2016/01/01China-Japan Friendship Hospital
  中国研究中心 1 个：Beijing
• 招募中NCT04300686
  A Pilot Study in Severe Patients With Takayasu Arteritis.
  IV 期 · 干预性 · 2020/03/01Shanghai Zhongshan Hospital
  中国研究中心 1 个：Shanghai
• 招募中NCT05102448
  Comparison of Tofacitinib and Methotrexate in Takayasu's Arteritis
  IV 期 · 干预性 · 2021/11/01Shanghai Zhongshan Hospital
  中国研究中心 1 个：Shanghai
• 招募中NCT06178419
  Remote Ischemic Conditioning for Cerebral Ischemia in Patients With Takayasu Arteritis (TARIC-1)
  不适用 · 干预性 · 2024/01/01Xuanwu Hospital, Beijing
  中国研究中心 1 个：Beijing
• 招募中NCT06498089
  A Randomized, Controlled, Open-label, Multicenter Clinical Trial Comparing the Efficacy and Safety of a Precision Treatment Regimen Based on Clinical-molecular Phenotypes with a Conventional Treatment Regimen in the Treatment of Patients with Active Takayasu's Arteritis
  IV 期 · 干预性 · 2024/06/28Shanghai Zhongshan Hospital
  中国研究中心 1 个：Shanghai
• 尚未开始招募NCT06766552
  A Registry Study Assessing PRO, Dosing Patterns, and Safety of Vunakizumab in Patients With General Rheumatic Diseases.
  观察性 · 2025/01/30Second Affiliated Hospital, Zhejiang University, School of Medicine
  中国研究中心 1 个：Hangzhou
• 尚未开始招募NCT07013838
  The Efficacy and Safety of Deucravacitinib in Takayasu's Arteritis
  IV 期 · 干预性 · 2025/06/15Chinese SLE Treatment And Research Group
  中国研究中心 1 个：Beijing
• 尚未开始招募NCT07451665
  Efficacy and Safety of Vunakizumab and Ivarmacitinib in the Treatment of Active Takayasu's Arteritis
  IV 期 · 干预性 · 2026/04/01Chinese SLE Treatment And Research Group
  中国研究中心 20 个：Baotou、Beijing、Chengdu、Ch’ang-ch’un、Guanzhou、Hangzhou 等 17 地

中国境外的在招试验 27L2

CT.gov 报告命中 27 项，此处取回并展示最近的 15 项。

• 尚未开始招募NCT07737470
  Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
  观察性 · 2026/09/01Assistance Publique - Hôpitaux de Paris
• 尚未开始招募NCT07571577
  Monitoring Disease Activity in Patients With Takayasu Arteritis With the OMERACT Takayasu Ultrasound Score (OTUS)
  观察性 · 2026/07/01IRCCS San Raffaele
• 尚未开始招募NCT07628075
  Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study.
  不适用 · 干预性 · 2026/07/01Imperial College London
  英国
• 尚未开始招募NCT07477795
  Phase II Interventional Study Evaluating Efficacy and Safety of Secukinumab in Active Severe Takayasu Patients
  II 期 · 干预性 · 2026/04/01Assistance Publique - Hôpitaux de Paris
• 招募中NCT07087912
  Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases
  IV 期 · 干预性 · 2026/03/16University of Sao Paulo General Hospital
  巴西
• 尚未开始招募NCT07325357
  Effect of Pirfenidone on TA Fibrosis
  IV 期 · 干预性 · 2025/12/20Shanghai Zhongshan Hospital
• 招募中NCT07077304
  EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
  观察性 · 2025/11/19Assistance Publique - Hôpitaux de Paris
  法国
• 招募中NCT07351422
  Investigating Management, Perspectives and Attitudes Towards Care in Takayasu Arteritis
  观察性 · 2025/10/01University of Edinburgh
  英国
• 招募中NCT07276087
  Physical and Psychosocial Parameters in Takayasu Arteritis and Behçet's Disease: A Comparative Study With Healthy Controls
  观察性 · 2025/09/11ÖZLEM NUR TOK YAMAN
  土耳其
• 招募中NCT07558382
  Global Initiative on Takayasu Arteritis (GITA)
  观察性 · 2025/08/05Marmara University
  土耳其
• 招募中NCT07491913
  Biologic Treatment Withdrawal in Takayasu Arteritis Patients in Sustained Remission
  不适用 · 干预性 · 2025/06/15Marmara University
  土耳其
• 招募中NCT06887062
  Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)
  II 期 · 干预性 · 2025/03/21University of Edinburgh
  英国
• 招募中NCT05904301
  Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases
  观察性 · 2023/06/21Santé Arménie French-Armenian Research Center
  Armenia
• 招募中NCT02967068
  VCRC Tissue Repository
  观察性 · 2016/11University of Pennsylvania
  加拿大、美国
• 招募中NCT02593565
  Vasculitis Pregnancy Registry
  观察性 · 2015/11University of Pennsylvania
  美国

外部标识与链接