巨细胞动脉周围炎

定义 英文原文（暂无中文）

A rare large vessel vasculitis (LVV) characterized by vasculitis predominantly involving the arteries originating from the aortic arch and the extracranial branches of the carotid arteries. Clinical manifestations are variable, the predominant cranial phenotype is characterized by headache, jaw claudication, scalp tenderness and visual symptoms and the predominant LVV type by constitutional symptoms, polymyalgia rheumatica and occasionally limb ischemia. Overlaps between these two phenotypes are common.

别名

颞动脉炎

基本事实

遗传方式

多基因/多因素

发病年龄

成年期

患病率

1-9 / 100 000（Germany）

相关基因 4

临床表型 73

近两年的全球研究 2,086L2

2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-10开放获取
  Study on the implementation of the 2015 EULAR/ACR recommendations for polymyalgia rheumatica in clinical practice
  RMD open · DOI · Europe PMC
• 2026-10开放获取
  Reduced humoral response to recombinant zoster vaccine in patients with SLE: a prospective cohort study across immune-mediated inflammatory diseases
  Lupus science & medicine · DOI · Europe PMC
• 2026-10病例报告开放获取
  Drug-Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion
  Pharmacology research & perspectives · DOI · Europe PMC
• 2026-10
  Diagnostic accuracy of musculoskeletal ultrasound in suspected polymyalgia rheumatica: a multicentre, cohort study
  The Lancet. Rheumatology · DOI · Europe PMC
• 2026-10荟萃分析系统综述综述
  Follow-Up 18F-Fluorodeoxyglucose Positron Emission Tomography in Treated Patients With Giant Cell Arteritis: A Systematic Review and Metaanalysis
  The Journal of rheumatology · DOI · Europe PMC
• 2026-10
  Structured Vascular Segment Analysis for Giant Cell Arteritis: A Proposed Scoring System for CTA-Based Diagnosis
  AJNR. American journal of neuroradiology · DOI · Europe PMC
• 2026-09
  Paracentral acute middle maculopathy in giant cell arteritis versus non-arteritic anterior ischaemic optic neuropathy
  The British journal of ophthalmology · DOI · Europe PMC
• 2026-09综述开放获取
  The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact
  Journal of immunotherapy and precision oncology · DOI · Europe PMC
• 2026-09
  The amalric sign: A clue to giant cell arteritis
  European journal of ophthalmology · DOI · Europe PMC
• 2026-09
  International practice patterns and beliefs concerning intravenous methylprednisolone and low-dose aspirin in giant cell arteritis
  Eye (London, England) · DOI · Europe PMC
• 2026-09开放获取
  Comparison of four clinical risk prediction models for the diagnosis of giant cell arteritis: results from the ongoing PREDICT-GCA study
  RMD open · DOI · Europe PMC
• 2026-09
  Impact of corticosteroid use on quality of life of people over 65 years of age with giant cell arteritis and/or polymyalgia rheumatica
  Geriatric nursing (New York, N.Y.) · DOI · Europe PMC
• 2026-09
  [Management of emergencies in rheumatology]
  Zeitschrift fur Rheumatologie · DOI · Europe PMC
• 2026-09
  Real-World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study
  Arthritis care & research · DOI · Europe PMC
• 2026-09综述开放获取
  Anti-obesity medications impacting the eye: An emerging concern - a narrative review
  World journal of methodology · DOI · Europe PMC
• 2026-09
  Infection Risk Associated with Steroid-Sparing Therapies in GCA, PMR, and ANCA-Associated Vasculitis: A Systematic Review
  Joint bone spine · DOI · Europe PMC
• 2026-09病例报告开放获取
  Silicoanthracosis: A melanoma mimicker
  Radiology case reports
• 2026-09
  Retraction: Association Between Baseline Aortic 18F-Fluorodeoxyglucose Uptake and Subsequent Aortic Dilatation in Giant Cell Arteritis: A Four-Year Post Hoc Analysis
  Cureus · DOI · Europe PMC
• 2026-09综述开放获取
  Bridging Autoimmunity and Hyperinflammation: Shared Immunological Pathways Among Autoimmune/Inflammatory Syndrome Induced by Adjuvants, Systemic Lupus Erythematosus, and Macrophage Activation Syndrome
  Biomedicines · DOI · Europe PMC
• 2026-09
  Orbital Inflammation can be visualized by black blood MRI in isolated polymyalgia rheumatica
  Rheumatology (Oxford, England) · DOI · Europe PMC

境外已获批用于本病的药物 3L2

欧盟 2 项、美国 1 项。同一药物在两地各批一次的，会分别列出。

• RoActemra欧盟2009-01-16
  tocilizumab
  官方记录
• Rinvoq欧盟2019-12-16
  upadacitinib
  官方记录
• Rinvoq美国2025-04-28
  upadacitinib
  官方记录

数据来自欧洲药品管理局（EMA）的药品与罕见病用药资格公开导出表，以及美国 FDA 的罕见病用药资格数据库（Orphan Drug Product Designation Database）。两边口径不同：欧盟一侧取的是当前状态仍为「已授权」的药品；美国一侧记录的是「曾获批准」这一事实，FDA 的公开表不追踪药物此后是否退市（例如 Relyvrio 于 2024 年撤市，表中仍记为已获批）。请以官方记录页为准。

在中国开展的临床试验 4L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 1

• 尚未开始招募NCT06766552
  A Registry Study Assessing PRO, Dosing Patterns, and Safety of Vunakizumab in Patients With General Rheumatic Diseases.
  观察性 · 2025/01/30Second Affiliated Hospital, Zhejiang University, School of Medicine
  中国研究中心 1 个：Hangzhou

中国境外的在招试验 55L2

CT.gov 报告命中 55 项，此处取回并展示最近的 15 项。

• 尚未开始招募NCT07269938
  Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA)
  观察性 · 2026/10University of Edinburgh
  英国
• 尚未开始招募NCT07737470
  Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
  观察性 · 2026/09/01Assistance Publique - Hôpitaux de Paris
• 尚未开始招募NCT07748195
  DNA Methylation in PMR
  观察性 · 2026/08/31Dartmouth-Hitchcock Medical Center
• 尚未开始招募NCT07749547
  Using Personalized Rehabilitation to Reduce Disease and Increase Activity of Patients With Polymyalgia Rheumatica
  不适用 · 干预性 · 2026/08/15Washington University School of Medicine
• 尚未开始招募NCT07132164
  Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE)
  观察性 · 2026/07/01University Hospital, Brest
  法国
• 尚未开始招募NCT07628075
  Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study.
  不适用 · 干预性 · 2026/07/01Imperial College London
  英国
• 尚未开始招募NCT06833411
  Treatment for Giant Cell Arteritis With Tocilizumab and 8 as Compared to 26 Weeks of Prednisone
  III 期 · 干预性 · 2026/07Insel Gruppe AG, University Hospital Bern
  瑞士
• 尚未开始招募NCT07720804
  Kinetics of C-Reactive Protein in Giant Cell Arteritis Following Glucocorticoid Initiation: A Pilot Study (GIDEON)
  不适用 · 干预性 · 2026/06/22University Hospital, Limoges
• 尚未开始招募NCT06957002
  Bosentan in the Treatment of Giant Cell Arteritis
  II 期 · 干预性 · 2026/06Assistance Publique - Hôpitaux de Paris
  法国
• 招募中NCT07286214
  Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica
  IV 期 · 干预性 · 2026/05/12Sanofi
  加拿大、美国
• 招募中NCT07552636
  Disease Activity Monitoring in Patients With Giant Cell Arteritis Study
  观察性 · 2026/05/06University of Aarhus
  丹麦
• 尚未开始招募NCT07508514
  Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCA
  观察性 · 2026/05/01Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
  加拿大
• 尚未开始招募NCT07354906
  Upadacitinib in Giant Cell Arteritis (GCA) With Active Large-vessel Involvement.
  观察性 · 2026/03/01Groupe français d'étude des Maladies Inflammatoires de loeil
  法国
• 招募中NCT07246577
  The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis.
  观察性 · 2026/03/01Vastra Gotaland Region
  瑞典
• 招募中NCT07060274
  Halo Sign Vanishing Time After Steroids Outbreak in GCA Patients
  不适用 · 干预性 · 2026/02/27Centre Hospitalier le Mans
  法国

外部标识与链接