高级别B细胞淋巴瘤合并MYC/BCL2/BLC6重排
High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
定义 英文原文（暂无中文）
A rare aggressive B-cell non-Hodgkin lymphoma characterized by a rearrangement in MYC and BCL2 and/or BCL6 (so-called double-hit or triple-hit lymphoma). The category includes double-hit cases with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma, blastoid cases with a double-hit, and cases with a DLBCL, not otherwise specified, morphology with a double-hit. It refers only to de novo cases, not to lymphomas with a history of pre-existing or coexistent indolent lymphoma. Patients typically present with widespread disease, including involvement of lymph nodes, bone marrow, and central nervous system.
基本事实
- 遗传方式
- 不适用
相关基因 3
| 基因 | 名称 | 关联类型 |
|---|---|---|
| BCL2 | BCL2 apoptosis regulator | Part of a fusion gene in |
| BCL6 | BCL6 transcription repressor | Part of a fusion gene in |
| MYC | MYC proto-oncogene, bHLH transcription factor | Part of a fusion gene in |
外部标识与链接
发现这一页有错误？告诉我 · 邮件主题会自动带上本页的 ORPHA 编号
本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）