口咽鳞状细胞癌
Squamous cell carcinoma of the oropharynx
ORPHA:500478疾病
定义 英文原文（暂无中文）
A rare head and neck tumor characterized by a malignant epithelial neoplasm with evidence of squamous differentiation, which may arise in association with high-risk HPV in a subset of cases. HPV-positive tumors have a strong predilection for the base of tongue and the palatine tonsils and typically present at an advanced clinical stage with cervical lymphadenopathy. They are associated with significantly better prognosis than HPV-negative tumors, which more commonly involve the soft palate, manifest as sore throat and difficulty in swallowing or a neck mass, and occur in older patients. Smoking and alcohol consumption are important risk factors.
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 青少年期、成年期、老年期
- 患病率
- 1-9 / 100 000（Europe）
相关基因 3
| 基因 | 名称 | 关联类型 |
|---|---|---|
| PTEN | phosphatase and tensin homolog | Disease-causing somatic mutation(s) in |
| ING1 | inhibitor of growth family member 1 | Disease-causing somatic mutation(s) in |
| TNFRSF10B | TNF receptor superfamily member 10b | Major susceptibility factor in |
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）