罕见病知识库 RareSeen

急性淋巴细胞性白血病

Acute lymphoblastic leukemia

ORPHA:513疾病组

定义 英文原文(暂无中文)

A group of rare Non-Hodgkin lymphoma characterized by malignant proliferation of lymphoid cells blocked at an early stage of differentiation. It accounts for 75% of all cases of childhood leukemia cases. The peak incidence occurs between 2 and 5 years of age. Patients may present with symptoms, frequently including lymphadenopathy, hepatosplenomegaly, bone pain, fever and signs of hemorrhage or they may remain asymptomatic. Some patients may also present with acute with a life-threatening hemorrhage, infection, or respiratory distress. Although it primarily affects the bone marrow and peripheral blood, the abnormal cells can infiltrate any organ or tissue.

别名

急性淋巴细胞白血病/淋巴瘤

基本事实

发病年龄
各年龄段
患病率
1-9 / 100 000(Europe)

相关基因 8来自下位疾病

Orphanet 未在本条目上直接标注致病基因。下表由本组所属的下位疾病汇总而来,「来源条目」列给出基因实际标注在哪一个 ORPHA 条目上。

基因名称来源条目
ATMATM serine/threonine kinaseORPHA:67038
CDKN2Acyclin dependent kinase inhibitor 2AORPHA:99861
CNOT3CCR4-NOT transcription complex subunit 3ORPHA:99861
FLT3fms related receptor tyrosine kinase 3ORPHA:99861
IKZF3IKAROS family zinc finger 3ORPHA:67038
POT1protection of telomeres 1ORPHA:67038
RPS15ribosomal protein S15ORPHA:67038
TP53tumor protein p53ORPHA:67038

外部标识与链接

发现这一页有错误?告诉我 · 邮件主题会自动带上本页的 ORPHA 编号

本页数据来源

  • 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
  • 中文病名:Orphanet 中文包,冻结于 2020-06-01
  • 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)