急性淋巴细胞性白血病
Acute lymphoblastic leukemia
定义 英文原文(暂无中文)
A group of rare Non-Hodgkin lymphoma characterized by malignant proliferation of lymphoid cells blocked at an early stage of differentiation. It accounts for 75% of all cases of childhood leukemia cases. The peak incidence occurs between 2 and 5 years of age. Patients may present with symptoms, frequently including lymphadenopathy, hepatosplenomegaly, bone pain, fever and signs of hemorrhage or they may remain asymptomatic. Some patients may also present with acute with a life-threatening hemorrhage, infection, or respiratory distress. Although it primarily affects the bone marrow and peripheral blood, the abnormal cells can infiltrate any organ or tissue.
别名
急性淋巴细胞白血病/淋巴瘤
基本事实
- 发病年龄
- 各年龄段
- 患病率
- 1-9 / 100 000(Europe)
相关基因 8来自下位疾病
Orphanet 未在本条目上直接标注致病基因。下表由本组所属的下位疾病汇总而来,「来源条目」列给出基因实际标注在哪一个 ORPHA 条目上。
| 基因 | 名称 | 来源条目 |
|---|---|---|
| ATM | ATM serine/threonine kinase | ORPHA:67038 |
| CDKN2A | cyclin dependent kinase inhibitor 2A | ORPHA:99861 |
| CNOT3 | CCR4-NOT transcription complex subunit 3 | ORPHA:99861 |
| FLT3 | fms related receptor tyrosine kinase 3 | ORPHA:99861 |
| IKZF3 | IKAROS family zinc finger 3 | ORPHA:67038 |
| POT1 | protection of telomeres 1 | ORPHA:67038 |
| RPS15 | ribosomal protein S15 | ORPHA:67038 |
| TP53 | tumor protein p53 | ORPHA:67038 |
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
- 中文病名:Orphanet 中文包,冻结于 2020-06-01
- 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)