急性粒-单核细胞白血病
Acute myelomonocytic leukemia
ORPHA:517疾病
定义 英文原文（暂无中文）
A rare acute myeloid leukemia disorder characterized by increased blast cells (myeloblasts, monoblast, and/or promonoblasts), representing more than 20% of the total bone marrow (BM) or peripheral blood differential counts, with 20-80% of BM cells being of monocytic lineage. Clinical presentation is the result of bone marrow involvement and extramedullary infiltration by the leukemic cells and includes asthenia, pallor, fever, dizziness, respiratory symptoms, easy bruising, bleeding disorders, and neurological deficits. Gingival hyperplasia, organomegaly, especially hepatosplenomegaly, and lymphadenopathy may also be associated.
别名
AML M4
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 成年期
- 患病率
- 1-9 / 1 000 000（Europe）
临床表型 9
极常见 99–80%3
- 贫血 HP:0001903
- 白细胞增多症 HP:0001974
- 血小板减少症 HP:0001873
常见 79–30%4
- 异常出血 HP:0001892
- 呼吸困难 HP:0002094
- 苍白圈 HP:0000980
- 体重减轻 HP:0001824
偶见 29–5%2
- 牙龈异常 HP:0000168
- 嗜酸性粒细胞增多症 HP:0001880
外部标识与链接
发现这一页有错误？告诉我 · 邮件主题会自动带上本页的 ORPHA 编号
本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）