CAR T细胞治疗相关的细胞因子释放综合征
T-cell based immunotherapy-associated cytokine release syndrome
定义 英文原文（暂无中文）
A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild, flu-like symptoms (such as fever, fatigue, headache, rash, arthralgia, and myalgia) to severe life-threatening manifestations including vascular leakage, disseminated intravascular coagulation, shock, and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).
别名
嵌合抗原受体-T细胞治疗相关的细胞因子释放综合征
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 成年期
临床表型 31
极常见 99–80%5
- 循环白细胞介素水平异常 HP:0011117
- 循环细胞因子水平异常 HP:0011112
- 疲乏 HP:0012378
- 发热 HP:0001945
- 炎症反应增强 HP:0012649
常见 79–30%6
- 低血压 HP:0002615
- 循环白细胞介素6水平升高 HP:0030783
- 循环γ干扰素浓度增加 HP:0030356
- 肌痛 HP:0003326
- 食欲不振 HP:0004396
- 心动过速 HP:0001649
偶见 29–5%16
- 心律失常 HP:0011675
- 毛细血管渗漏 HP:0030005
- 意识模糊 HP:0001289
- 少尿 HP:0011037
- 腹泻 HP:0002014
- 血清肌酐水平升高 HP:0003259
- 循环肝转氨酶水平升高 HP:0002910
- 心脏传导阻滞 HP:0012722
- 高胆红素血症 HP:0002904
- 低氧血症 HP:0012418
- 恶心 HP:0002018
- 胸腔积液 HP:0002202
- 肺水肿 HP:0100598
- 左心室射血分数降低 HP:0012664
- 呼吸过速 HP:0002789
- 呕吐 HP:0002013
罕见 <4–1%4
- 急性肾损伤 HP:0001919
- 弥漫性血管内凝血 HP:0005521
- 呼吸衰竭 HP:0002878
- 皮疹 HP:0000988
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）