跖骨软骨病
Osteochondrosis of the metatarsal bone
ORPHA:564003疾病
定义 英文原文(暂无中文)
A rare bone disease characterized by avascular necrosis of a metatarsal head, most commonly involving the second, but also the third or fourth, metatarsal. Patients may present with pain on weight-bearing, swelling, and tenderness. Radiological features include widening of the metatarsophalangeal joint space and flattening of the affected metatarsal head, at later stages metatarsal head sclerosis, cortical thickening, and intra-articular loose bodies. The condition can be bilateral in some cases and shows a significant predilection for females in the second or third decade of life.
别名
跖骨无菌性坏死
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 青少年期、成年期
临床表型 19
常见 79–30%15
- 跖骨骨骺形态异常 HP:0010630
- 第二跖骨异常 HP:0040034
- 关节疼痛 HP:0002829
- 关节炎 HP:0001369
- 软骨炎 HP:0100662
- 扁平跖骨头 HP:0005194
- 足痛 HP:0025238
- 步态异常 HP:0001288
- 关节僵硬 HP:0001387
- 骨软骨炎 HP:0040188
- 下肢水肿 HP:0010741
- 关节渐进性受损 HP:0005187
- 足骨硬化 HP:0100925
- 足结构性畸形 HP:0010219
- 骨皮质增厚 HP:0100039
偶见 29–5%2
- 第三跖骨异常 HP:0010672
- 缺血性坏死 HP:0010885
罕见 <4–1%2
- 第五跖骨异常 HP:0008089
- 第四跖骨异常 HP:0040035
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
- 中文病名:Orphanet 中文包,冻结于 2020-06-01
- 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)