Acute myeloid leukemia with t(9;22)(q34.1;q11.2)

定义 英文原文（暂无中文）

A rare acute myeloid leukemia (AML) with recurrent genetic anomaly characterized by the presence of bone marrow and peripheral blood myeloblasts with features ranging from those of minimal differentiation to granulocytic maturation, demonstrating t(9;22)(q34.1;q11.2) or molecular genetic evidence of BCR-ABL1 fusion. Evidence of chronic myeloid leukemia (CML) is absent. Patients most commonly present with leukocytosis with blast predominance and variable anemia and thrombocytopenia. Splenomegaly is less frequent and peripheral blood basophilia lower than in patients with myeloid blast transformation of CML. The disease occurs primarily in adults, and response to traditional AML therapy or tyrosine kinase inhibitor therapy alone is typically poor.

别名

AML with BCR-ABL1、AML with t(9;22)(q34.1;q11.2)

基本事实

遗传方式

不适用

发病年龄

青少年期、成年期、儿童期、老年期、婴儿期、新生儿期

患病率

1-9 / 100 000

外部标识与链接