Acquired hemophilia A

别名

AHA、Acquired F8 deficiency、Acquired factor VIII deficiency

基本事实

遗传方式

不适用

发病年龄

青少年期、成年期、儿童期、老年期

患病率

1-9 / 1 000 000（Europe）

近两年的全球研究 267L2

2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-09病例报告开放获取
  When A Fall Isn't Just a Fall: Delayed Diagnosis of Acquired Hemophilia A in a Nonagenarian Patient
  The American journal of case reports · DOI · Europe PMC
• 2026-09病例报告
  Teclistamab in relapsed, multi-refractory acquired hemophilia A after failure of anti-CD19 CAR-T cell therapy
  Journal of thrombosis and haemostasis : JTH · DOI · Europe PMC
• 2026-09开放获取
  Time- and Temperature-Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management
  Journal of clinical laboratory analysis · DOI · Europe PMC
• 2026-09综述开放获取
  Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: A Systematic Review
  Clinical Medicine Insights. Oncology · DOI · Europe PMC
• 2026-09开放获取
  Kunihiro Hattori, Tomoyuki Igawa, and Takehisa Kitazawa share Lasker Award honors for revolutionary hemophilia A therapy
  The Journal of clinical investigation · DOI · Europe PMC
• 2026-09
  Acquired hemophilia: insights from a multicenter real-life study in a middle-income country
  Blood coagulation & fibrinolysis : an international journal in haemost · DOI · Europe PMC
• 2026-09
  Acquired hemophilia A following wasp stings: a case report
  World journal of emergency medicine · DOI · Europe PMC
• 2026-09
  Acquired hemophilia A following wasp stings: a case report
  World Journal of Emergency Medicine
• 2026-09系统综述
  Oral Clues to Undiagnosed Congenital Hemophilia: A Systematic Review of Case Reports
  Special care in dentistry : official publication of the American Assoc · DOI · Europe PMC
• 2026-09
  Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue
  Journal of clinical apheresis · DOI · Europe PMC
• 2026-09综述病例报告开放获取
  Acquired hemophilia a caused by complicated urinary tract infection due to flavobacterium odoratum: A case report and literature review
  Medicine · DOI · Europe PMC
• 2026-09开放获取
  Cardiovascular risk scores estimate arterial thrombotic risk in aging adults with hemophilia in the ADVANCE Japan cohort
  Blood advances · DOI · Europe PMC
• 2026-08
  Remission-driven discontinuation shapes the observed duration of emicizumab in acquired hemophilia A. Comment on: "Short-term emicizumab in patients with acquired hemophilia A"
  Haematologica · DOI · Europe PMC
• 2026-08
  Mortality and Relapse Patterns in Acquired Hemophilia A: A Single-Centre Experience and Systematic Review With Proportional Meta-Analysis
  Haemophilia : the official journal of the World Federation of Hemophil · DOI · Europe PMC
• 2026-08开放获取
  Autoimmune Reporting Signals in FAERS Reports Listing COVID-19 Vaccines as Suspect Products: An Active-Comparator Disproportionality Analysis
  International journal of environmental research and public health · DOI · Europe PMC
• 2026-08综述开放获取
  Targeting CD38 Across Autoimmune and Plasma Cell-Driven Immune-Mediated Diseases: Rationale, Clinical Evidence, and Emerging Therapeutic Landscape
  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene th · DOI · Europe PMC
• 2026-08综述开放获取
  Hematological Toxicities in the Modern Era of Melanoma Therapy
  Journal of clinical medicine · DOI · Europe PMC
• 2026-08病例报告
  Case Report: When Routine Gynecologic Procedures Unmask a Systemic Bleeding Disorder: Refractory Uterine Hemorrhage Leading to the Diagnosis of AL Amyloidosis
  The journal of obstetrics and gynaecology research · DOI · Europe PMC
• 2026-07病例报告开放获取
  Acquired Hemophilia A in an Elderly Patient Receiving Clopidogrel: Drug-Induced or Age-Associated Autoimmunity?
  Cureus · DOI · Europe PMC
• 2026-07开放获取
  Hematoma, Hemarthrosis, and Hemotympanum: A Case Report of Acquired Hemophilia A
  Journal of education & teaching in emergency medicine · DOI · Europe PMC

国家医保药品目录中点名本病的药品 1L2

出自《国家基本医疗保险、生育保险和工伤保险药品目录（2025年）》（医保发〔2025〕33号，2026-01-01 起执行）。下列药品在药品名称或限定支付范围里出现了本病的名称。

• 注射用重组人凝血因子Ⅶa乙类西药
  限下列患者群体出血的治疗，以及外科手术或有创操作出血的防治：1.凝血因子Ⅷ或Ⅸ的抑制物＞5个Bethesda单位(BU)的先天性血友病患者；预计对注射凝血因子Ⅷ或凝血因子Ⅸ，具有高记忆应答的先天性血友病患者；2.获得性血友病患者；3.先天性凝血因子Ⅶ(FⅦ)缺乏症患者；4.具有血小板膜糖蛋白Ⅱb-Ⅲa(GPⅡb-Ⅲa)和/或人白细胞抗原(HLA)抗体和既往或现在对血小板输注无效或不佳的血小板无力症患者。

在中国开展的临床试验 6L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 3

• 招募中NCT05849740
  An Exploratory Study of Cluster of Differentiation 38 (CD38) Monoclonal Antibody Combined Corticosteroid in Acquired Hemophilia A
  IV 期 · 干预性 · 2023/05/22Institute of Hematology & Blood Diseases Hospital, China
  中国研究中心 1 个：Tianjin
• 招募中NCT06727669
  Longitudinal Cohort of Thrombosis and Hemostasis Diseases
  观察性 · 2024/11/01Peking University People's Hospital
  中国研究中心 5 个：Beijing、Chongqing、Zhengzhou
• 尚未开始招募NCT07789587
  A Study of Bometase Alfa for Bleeding Control in Acquired Hemophilia A
  不适用 · 干预性 · 2026/08Institute of Hematology & Blood Diseases Hospital, China
  中国研究中心 1 个：Tianjin

中国境外的在招试验 5L2

CT.gov 报告命中 5 项，此处取回并展示最近的 2 项。

• 招募中NCT06550882
  A Study of OBIZUR in Adults With Acquired Hemophilia A (AHA) in South Korea
  观察性 · 2025/07/22Takeda
  韩国
• 招募中NCT06461533
  A Survey of Susoctocog Alfa (Genetical Recombination) in Participants With Acquired Haemophilia A
  观察性 · 2024/06/10Takeda
  日本

外部标识与链接