Acquired hemophilia B

别名

AHB、Acquired F9 deficiency、Acquired factor IX deficiency

基本事实

遗传方式

不适用

发病年龄

成年期、儿童期、老年期

近两年的全球研究 266L2

2024/08 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-07
  Hematoma, Hemarthrosis, and Hemotympanum: A Case Report of Acquired Hemophilia A
  Journal of education & teaching in emergency medicine · DOI · Europe PMC
• 2026-07病例报告
  Acquired Hemophilia A Revealing Occult Splenic Marginal Zone Lymphoma
  The American journal of case reports · DOI · Europe PMC
• 2026-07
  Short-term emicizumab in patients with acquired hemophilia A
  Haematologica · DOI · Europe PMC
• 2026-07病例报告
  Prepartum Acquired Hemophilia A: Managing a Double Challenge for Mother and Child
  Journal of thrombosis and haemostasis : JTH · DOI · Europe PMC
• 2026-07
  Acquired Autoimmune Factor XIII Deficiency as a Novel Immune-Related Adverse Event of Combined Ipilimumab and Nivolumab Therapy for Renal Cell Carcinoma: A Case Report
  IJU case reports · DOI · Europe PMC
• 2026-07
  Transfer of emicizumab into breast milk in postpartum acquired hemophilia A
  Journal of thrombosis and haemostasis : JTH · DOI · Europe PMC
• 2026-07
  Sequential Use of Recombinant Porcine Factor VIII and Early Emicizumab in Acquired Hemophilia A: A Case Series
  EJHaem · DOI · Europe PMC
• 2026-06
  A novel humanized FIX/FX hemophilia A mouse model for preclinical evaluation of FVIIIa-mimetic bispecific antibodies
  Blood advances · DOI · Europe PMC
• 2026-06病例报告开放获取
  Refractory Hemorrhage Following Total Knee Replacement Unmasking Acquired Hemophilia A
  Cureus · DOI · Europe PMC
• 2026-06综述病例报告
  Acquired hemophilia A following influenza vaccination: a case report and literature review
  Annals of hematology · DOI · Europe PMC
• 2026-06开放获取
  Publication Only
  HemaSphere
• 2026-06
  [Impact of effective health information acquisition on hemophilia-related health literacy among caregivers of underage hemophilia patients]
  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Hea · DOI · Europe PMC
• 2026-05综述开放获取
  MAGa: Monoclonal Autoimmune Gammopathies
  Cancers · DOI · Europe PMC
• 2026-05
  Role of cross-mixing tests in differentiating etiologies of prolonged aPTT: a single-center retrospective study
  International journal of hematology · DOI · Europe PMC
• 2026-05开放获取
  Biologics and Drug-Induced Immunogenicity: A Case Report of Acquired Hemophilia A Presenting After Immunotherapy
  Clinical case reports · DOI · Europe PMC
• 2026-05病例报告
  Successful Perioperative Management of Pregnancy-Related Acquired Hemophilia A Using Only Bypassing Agents: A Case Report
  A&A practice · DOI · Europe PMC
• 2026-05病例报告开放获取
  Idiopathic Acquired Hemophilia A With High-Titer Factor VIII Inhibitor in an Elderly Patient: A Case Report
  Cureus · DOI · Europe PMC
• 2026-05
  Intracranial hemorrhage in acquired hemophilia A: illustrative case
  Journal of neurosurgery. Case lessons · DOI · Europe PMC
• 2026-05开放获取
  The problem with one-size-fits-all medicine: Biological sex and the aging immune system
  PLoS biology · DOI · Europe PMC
• 2026-05
  Incidence of infections in patients treated with rituximab for autoimmune disorders of hematological Interest or non-Hodgkin lymphoma
  Annals of hematology · DOI · Europe PMC

国家医保药品目录中点名本病的药品 1L2

出自《国家基本医疗保险、生育保险和工伤保险药品目录（2025年）》（医保发〔2025〕33号，2026-01-01 起执行）。下列药品在药品名称或限定支付范围里出现了本病的名称。

• 注射用重组人凝血因子Ⅶa乙类西药
  限下列患者群体出血的治疗，以及外科手术或有创操作出血的防治：1.凝血因子Ⅷ或Ⅸ的抑制物＞5个Bethesda单位(BU)的先天性血友病患者；预计对注射凝血因子Ⅷ或凝血因子Ⅸ，具有高记忆应答的先天性血友病患者；2.获得性血友病患者；3.先天性凝血因子Ⅶ(FⅦ)缺乏症患者；4.具有血小板膜糖蛋白Ⅱb-Ⅲa(GPⅡb-Ⅲa)和/或人白细胞抗原(HLA)抗体和既往或现在对血小板输注无效或不佳的血小板无力症患者。

在中国开展的临床试验 5L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

登记为可入组 2

• 招募中NCT05849740
  An Exploratory Study of Cluster of Differentiation 38 (CD38) Monoclonal Antibody Combined Corticosteroid in Acquired Hemophilia A
  IV 期 · 干预性 · 2023/05/22Institute of Hematology & Blood Diseases Hospital, China
  中国研究中心 1 个：Tianjin
• 招募中NCT06727669
  Longitudinal Cohort of Thrombosis and Hemostasis Diseases
  观察性 · 2024/11/01Peking University People's Hospital
  中国研究中心 5 个：Beijing、Chongqing、Zhengzhou

中国境外的在招试验 4L2

CT.gov 报告命中 4 项，此处取回并展示最近的 2 项。

• 招募中NCT06550882
  A Study of OBIZUR in Adults With Acquired Hemophilia A (AHA) in South Korea
  观察性 · 2025/07/22Takeda
  韩国
• 招募中NCT06461533
  A Survey of Susoctocog Alfa (Genetical Recombination) in Participants With Acquired Haemophilia A
  观察性 · 2024/06/10Takeda
  日本

外部标识与链接