Narcolepsy
别名
Narcolepsy with or without cataplexy
近两年的全球研究 2,897L2
2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。
- 2026-10综述What can narcolepsy teach us about hypocretin and dementia?
- 2026-10Preceding night sleep time and multiple sleep latency test outcomes
- 2026-10开放获取Re: "Palliative Care in Europe: Safeguarding Compassion Amidst Changing End-of-Life Policies and Expanding Access to Medically Assisted Dying Position Statement on Behalf of the European Academy of Neurology, the European Federation of Neurological Associations and OneNeurology"
- 2026-10Big data and psychiatry: advances, constraints and future directions
- 2026-10Orexin receptor agonist secures landmark narcolepsy approval
- 2026-10开放获取Circadian Genotypes in PER3 and Time of Prostate Cancer Radiotherapy Interact to Affect Risk of Late Side Effects
- 2026-09Sleep macro-architecture in sleep-deprivation-sensitive and sleep-deprivation-insensitive juvenile myoclonic epilepsy: A polysomnographic study
- 2026-09The German version of the Sleep Inertia Questionnaire in central disorders of hypersomnolence: a validation study
- 2026-09开放获取Sleep as a psychiatric vital sign, not just a symptom
- 2026-09Development and Preliminary Evaluation of the Wilder-Addison Narcolepsy Function Scale for Occupational Performance
- 2026-09Management of residual excessive daytime sleepiness in depression: An AFPBN consensus using the nominal group technique
- 2026-09开放获取Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis
- 2026-09开放获取A New Electrophysiological Approach to Sleep Microstructure: The Gülhane Classification of K-Complex Subtypes in Narcolepsy Type 1 and Type 2
- 2026-09Analytical evaluation and method comparison of an orexin-A radioimmunoassay in cerebrospinal fluid: establishing a cut-off value for type 1 narcolepsy and exploring genetic and clinical characteristics
- 2026-09Candidate biomarkers in narcolepsy in H1N1-vaccinated cohorts: A proteomic and transcriptomic study
- 2026-09Foundation Models in Sleep Research: Opportunities and Limitations
- 2026-09Exploration and Analysis of Traditional Chinese Medicine Syndrome Differentiation of Insomnia Based on Millimeter-Wave Radar
- 2026-09Narcolepsy
- 2026-09How the Albert Lasker Winners Identified Orexin and Elucidated the Peptide's Role in Narcolepsy
- 2026-09The Orexin System-A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy: The 2026 Albert Lasker Basic Medical Research Award
国家医保药品目录中点名本病的药品 1L2
出自《国家基本医疗保险、生育保险和工伤保险药品目录（2025年）》（医保发〔2025〕33号，2026-01-01 起执行）。下列药品在药品名称或限定支付范围里出现了本病的名称。
匹配不到 ≠ 不能报销。目录里只有约一成药品设了限定支付范围，其余按适应症正常使用同样可报销；本区块只能回答「目录有没有点名这个病」，不能回答「这个病有没有药能报销」。各省执行细则、双通道与单独支付范围另有规定，请以当地医保部门口径为准。
- 盐酸替洛利生片乙类谈判药品限发作性睡病6岁及以上患者。
境外已获批用于本病的药物 8L2
欧盟 3 项、美国 5 项。同一药物在两地各批一次的，会分别列出。
「境外已获批」不等于「在中国能用」。中间隔着进口注册、临床急需境外新药通道、海南博鳌乐城国际医疗旅游先行区等几条路径，各有各的条件与费用。这一节能确定地告诉你的只有一件事：这个病在世界范围内已经有获得批准的药物，它叫什么名字。拿这个名字去问主治医生，是下一步最省力的做法。
药名一律保留英文原文，不作翻译——中国的药品通用名与英文名的音译经常不一致，译错会让人去找一个不存在的药。
- Xyrem欧盟2005-10-13sodium oxybate官方记录
- Wakix欧盟2016-03-31pitolisant官方记录
- Sunosi欧盟2020-01-16solriamfetol官方记录
- Provigil美国1998-12-24Modafinil官方记录
- Xyrem美国2002-07-17sodium oxybate官方记录
- Sunosi美国2019-06-17Solriamfetol官方记录
- WAKIX美国2019-08-14Pitolisant官方记录
- Xywav美国2020-07-21calcium, magnesium, potassium, and sodium oxybates官方记录
尚未获批的在研药物（11 项）
这些药已被欧盟或美国的监管机构认定为罕见病用药（英文 orphan drug designation，中文行业里通称「孤儿药资格」——「孤儿」说的是这类药市场太小、没有厂商愿意认领，不是在说病人）。但这只是一种监管身份：意味着监管机构给予研发上的激励，不代表这个药已被证明有效，也不代表将来一定能上市，绝大多数最终不会成药。列在这里是为了看清有哪些方向正在被尝试。
- Mazindol欧盟2015-10-09Treatment of narcolepsy官方记录
- tropatepine hydrochloride欧盟2022-03-16Treatment of narcolepsy官方记录
- sodium oxybate欧盟2023-10-13Treatment of narcolepsy官方记录
- N-{(2S,3R)-4,4-Difluoro-1-(2-hydroxy-2-methylpropanoyl)-2-[(2,3',5'-tr欧盟2023-11-08Treatment of narcolepsy官方记录
- alixorexton欧盟2026-05-20Treatment of narcolepsy官方记录
- Gamma hydroxybutyrate美国1987-12-03Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations and automatic behavior.官方记录
- mazindol美国2016-07-06Treatment of narcolepsy官方记录
- pentetrazol美国2017-03-16Treatment of narcolepsy官方记录
- reboxetine美国2018-10-15Treatment of narcolepsy官方记录
- 4-((L-valyl)oxy)butanoic acid美国2019-06-12Treatment of Narcolepsy官方记录
- oveporexton美国2026-03-02treatment of narcolepsy type 1 (narcolepsy with cataplexy)官方记录
数据来自欧洲药品管理局（EMA）的药品与罕见病用药资格公开导出表，以及美国 FDA 的罕见病用药资格数据库（Orphan Drug Product Designation Database）。两边口径不同：欧盟一侧取的是当前状态仍为「已授权」的药品；美国一侧记录的是「曾获批准」这一事实，FDA 的公开表不追踪药物此后是否退市（例如 Relyvrio 于 2024 年撤市，表中仍记为已获批）。请以官方记录页为准。
在中国开展的临床试验 14L2
按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。
登记为可入组 7
- 招募中NCT06279247Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy中国研究中心 1 个：Jinan
- 招募中NCT06797284The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders中国研究中心 1 个：Suzhou
- 招募中NCT06952699A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)中国研究中心 4 个：Beijing、Changchun、Guangzhou、Shanghai
- 招募中NCT07493265A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy中国研究中心 8 个：Beijing、Changchun、Guangdong、Guangzhou、Jinan、Nanchang 等 8 地
- 招募中NCT07633301A Study of TAK-360 in Adults With Narcolepsy Type 1 (Narcolepsy With Cataplexy)中国研究中心 3 个：Beijing、Guangzhou、Zhengzhou
- 招募中NCT07646678A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia中国研究中心 3 个：Guangzhou、Xicheng、Zhenzhou
- 招募中NCT07727239Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1中国研究中心 1 个：Xi'an
其他状态的试验（7 项）
- 已完成NCT00061022Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke中国研究中心 3 个：Beijing、Guangzhou、Shanghai
- 状态未知NCT03376568Investigation of Clinical Feature and Brain Function in Narcoleptic Patients中国研究中心 1 个：Xi'an
- 已终止NCT04096560A Study of TAK-994 in Adults With Type 1 and Type 2 Narcolepsy中国研究中心 4 个：Beijing、Changchun、Shanghai、Tianhe
- 状态未知NCT04940806The Value of Combined Detection of Orexin-A, HLA Gene, PSG and MSLT in the Evaluation of Patients With Narcolepsy中国研究中心 1 个：Jinan
- 已完成NCT06241911Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Narcolepsy Type 1中国研究中心 1 个：Xi'an
- 已完成NCT06505031A Study of TAK-861 in People With Narcolepsy Type 1中国研究中心 4 个：Beijing、Guangdong、Shanghai、Zhengzhou
- 进行中·不再招募NCT07654803Radar Sleep Monitoring in Type 1 Narcolepsy: Feasibility中国研究中心 1 个：Xi'an
中国境外的在招试验 36L2
这些试验在中国没有研究中心，通常无法直接报名——入组一般要求在当地居住并接受随访。列在这里是因为它另有用处：看清楚全世界正在试哪些药、做到了哪一期、由谁在做。把药名和 NCT 编号记下来去问主治医生，或据此进一步查该药是否已在境外获批、是否有拓展性用药（expanded access）通道。
美国18法国13加拿大6澳大利亚6意大利6西班牙6荷兰4比利时3日本3芬兰2德国2波兰1捷克1挪威1另有 2 个国家/地区
CT.gov 报告命中 36 项，此处取回并展示最近的 15 项。
- 尚未开始招募NCT07766343Hypersomnia in the Paediatric Population法国
- 招募中NCT07540364A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)美国
- 招募中NCT07540897A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304)加拿大、波兰、美国
- 招募中NCT07625280A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH美国
- 招募中NCT06383806Decreasing Nightmares in Adults With Narcolepsy美国
- 招募中NCT07675135A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy加拿大、美国
- 招募中NCT07598708A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence美国
- 招募中NCT07584434A Phase 1, First-in-human Study of VX-433美国
- 招募中NCT07502443A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2澳大利亚、比利时、加拿大、法国、意大利、日本、荷兰、西班牙 等 9 国
- 招募中NCT07455383A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1澳大利亚、比利时、加拿大、法国、意大利、日本、荷兰、西班牙 等 9 国
- 招募中NCT07365566Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder法国
- 招募中NCT06809803Extended-release Sodium Oxybate in Children美国
- 招募中NCT07096674A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia加拿大、意大利、西班牙、美国
- 招募中NCT07006233A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia澳大利亚
- 招募中NCT07613710A Trial to Test the Safety and Tolerability of Lu AH69593 in Adults That Are Healthy or Have Narcolepsy芬兰
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01；本条目在该版本中无中文名
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）