Autoimmune encephalitis
别名
AE、AIE
近两年的全球研究 3,564L2
2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。
- 2026-10Rapidly Evolving Aphasia as a Diagnostic Clue in First-Episode Psychosis: A Case Report of Anti-NMDAR Encephalitis
- 2026-10综述From immune dysregulation to precision immunotherapy in psychiatric disorders: A clinical-readiness framework for biomarkers and trials
- 2026-10病例报告Clinical Reasoning: A 13-Year-Old Boy With Acute-Onset Generalized Dystonia, Rostrocaudal Gradient, and Severe Bulbar Dysfunction
- 2026-10综述开放获取Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases
- 2026-10综述开放获取The role of IRF5 as an immune regulator
- 2026-10综述Toward a Phase-Based Biological Stratification of Autism Spectrum Disorder: A Neuroinflammatory Developmental Framework
- 2026-10The WPA Neuropsychiatry Special Interest Group: charting the way forward for neuropsychiatry
- 2026-10病例报告A 6-Year-Old With Becker Muscular Dystrophy and Catatonia
- 2026-10开放获取CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser-Induced Lesions
- 2026-09开放获取Clinical Characteristics of Japanese Cases of Anti-Metabotropic Glutamate Receptor Type 1 Antibody-Associated Cerebellar Ataxia
- 2026-09综述开放获取The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact
- 2026-09Sudden Neurological Decline Following HSV Encephalitis: A Clinical Vignette
- 2026-09病例报告Acrodynia and CASPR2 Autoimmunity in Elemental Mercury Toxicity
- 2026-09Aggressive Retinal vasculitis and Progressive Outer Retinal Atrophy Associated with Sjögren's Syndrome: A Case Report
- 2026-09开放获取Utility of the APE<sup>2</sup> Score as a Diagnostic Tool for Autoimmune Encephalitis
- 2026-09开放获取Ofatumumab Therapy and Long-Term Seizure Outcomes of Patients With Relapsing Anti-NMDA Receptor Encephalitis
- 2026-09综述Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network
- 2026-09Regulation of protein kinase pathways in primary neuron model of anti-NMDA receptor encephalitis
- 2026-09开放获取Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis
- 2026-09综述[Autoimmune encephalitis in intensive care medicine : Differentiation from infectious encephalitis]
境外已获批用于本病的药物 0L2
欧盟与美国均未检索到已获批用于本病的药物。
尚未获批的在研药物（1 项）
这些药已被欧盟或美国的监管机构认定为罕见病用药（英文 orphan drug designation，中文行业里通称「孤儿药资格」——「孤儿」说的是这类药市场太小、没有厂商愿意认领，不是在说病人）。但这只是一种监管身份：意味着监管机构给予研发上的激励，不代表这个药已被证明有效，也不代表将来一定能上市，绝大多数最终不会成药。列在这里是为了看清有哪些方向正在被尝试。
- satralizumab-mwge美国2022-07-18Treatment of N-methyl-D-asparatate receptor (NMDAR) antibody autoimmune encephalitis (AIE)官方记录
数据来自欧洲药品管理局（EMA）的药品与罕见病用药资格公开导出表，以及美国 FDA 的罕见病用药资格数据库（Orphan Drug Product Designation Database）。两边口径不同：欧盟一侧取的是当前状态仍为「已授权」的药品；美国一侧记录的是「曾获批准」这一事实，FDA 的公开表不追踪药物此后是否退市（例如 Relyvrio 于 2024 年撤市，表中仍记为已获批）。请以官方记录页为准。
在中国开展的临床试验 25L2
按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。
登记为可入组 15
- 招募中NCT04561557Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous System中国研究中心 1 个：Wuhan
- 招募中NCT06173076A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis中国研究中心 1 个：Hangzhou
- 招募中NCT06388161Neural Autoantibody Prevalence in New-onset Focal Seizures of Unknown Etiology中国研究中心 1 个：Hangzhou
- 招募中NCT07653984Cohort Study on Neuroimmune Diseases in the Reproductive Age中国研究中心 1 个：Guangzhou
- 招募中NCT06502015Biomarkers in Autoimmune Disease of Nervous System中国研究中心 1 个：Wuhan
- 招募中NCT06584045Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis)中国研究中心 1 个：Wuhan
- 招募中NCT06867991Safety and Efficacy of Combined B Cell Depleting theRapy And Daratumumab In Autoimmune Encephalitis中国研究中心 2 个：Changzhou、Zhengzhou
- 招募中NCT06510283Efficacy and Safety of Taitacept in Treatment of Refractory or Recurrent Anti-NMDAR/anti-LGI1 Encephalitis中国研究中心 1 个：Beijing
- 尚未开始招募NCT06760091A Multicentric Cohort of Autoimmune Encephalitis中国研究中心 1 个：Beijing
- 招募中NCT06939166Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases中国研究中心 1 个：Tianjin
- 招募中NCT07337785CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases中国研究中心 1 个：Wuhan
- 尚未开始招募NCT07333196Tongji NADs Cohort中国研究中心 1 个：Wuhan
- 招募中NCT07526493Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.中国研究中心 1 个：Wuhan
- 尚未开始招募NCT07686042Efficacy and Safety of Low-Dose Blinatumomab in the Treatment of Refractory Autoimmune Encephalitis and Autoimmune Cerebellitis中国研究中心 1 个：Beijing
- 招募中NCT07822776Efgartigimod in Anti-NMDA Receptor Encephalitis.中国研究中心 1 个：Beijing
其他状态的试验（10 项）
- 状态未知NCT02443350Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in Beijing Area中国研究中心 1 个：Beijing
- 已完成NCT07722286Relapse and Functional Outcomes in Anti-LGI1 Encephalitis中国研究中心 1 个：Hangzhou
- 已完成NCT03530462To Explore Cognitive Neural Mechanism of Autoimmune Encephalitis by Using Neuropsychological Tests and Multi-modal MRI中国研究中心 1 个：Hangzhou
- 状态未知NCT05422664Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy中国研究中心 1 个：Xi'an
- 已完成NCT03542279CPI Combination Therapy for Autoimmune Encephalitis中国研究中心 1 个：Beijing
- 状态未知NCT06443333National, Multicentric Registry Study on Neuroimmunological Diseases in China中国研究中心 1 个：Beijing
- 已完成NCT07036042Clinical Characteristics of Patients With Anti-Collapsin Response Mediator Protein 2 Antibodies in Encephalitis or Encephalomyelitis中国研究中心 1 个：Guangzhou
- 状态未知NCT05414890Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen Determination中国研究中心 1 个：Beijing
- 进行中·不再招募NCT05503264A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis中国研究中心 8 个：Beijing、Chengdu、Fuzhou、Jining、Shanghai、Wenzhou
- 已完成NCT06033846Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis中国研究中心 1 个：Xi'an
中国境外的在招试验 46L2
这些试验在中国没有研究中心，通常无法直接报名——入组一般要求在当地居住并接受随访。列在这里是因为它另有用处：看清楚全世界正在试哪些药、做到了哪一期、由谁在做。把药名和 NCT 编号记下来去问主治医生，或据此进一步查该药是否已在境外获批、是否有拓展性用药（expanded access）通道。
法国9美国7意大利3西班牙2英国1埃及1韩国1加拿大1荷兰1德国1瑞士1
CT.gov 报告命中 46 项，此处取回并展示最近的 15 项。
- 尚未开始招募NCT07783269A Basket Study of CTA313 in Participants With Active Autoimmune Diseases
- 尚未开始招募NCT07791212Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases英国
- 尚未开始招募NCT07804004A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease
- 招募中NCT07583641A Study to Learn About How Well the Medicine Efgartigimod Works to Treat Autoimmune Encephalitis In Children 12 Years or Older and Adults美国
- 招募中NCT07707739Plasma Exchange in Pediatric Autoimmune Encephalitis埃及
- 招募中NCT07732907Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia美国
- 招募中NCT07093333A Study in Participants With Anti-NMDAR Encephalitis and Anti-NMDAR Autoantibody-Associated Psychiatric Disease韩国
- 招募中NCT07488117Is [18F]-DPA-714 PET a Good Marker of Neuroinflammation in Autoimmune Encephalitis?法国
- 尚未开始招募NCT07341828A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy
- 招募中NCT07158229Long-term Impact of NMDAR Encephalitis, Level 3法国
- 招募中NCT06863974High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in Immune Cell Network法国
- 尚未开始招募NCT07131683hUC-MSC-Exo Therapy for Autoimmune Encephalitis
- 招募中NCT07477015Study of Pathogenic Mechanisms and Identification of Novel Autoantibodies in Autoimmune Encephalitis意大利
- 尚未开始招募NCT0685114318F-DPA-714 PET/MR in Dysfunctional Brain Diseases
- 尚未开始招募NCT06697678Risk Prediction Model for Severe Autoimmune Encephalitis
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01；本条目在该版本中无中文名
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）