Autoimmune encephalitis
别名
AE、AIE
近两年的全球研究 3,291L2
2024/08 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。
- 2026-08Erratum: Unclassified Neuronal Antibodies in Suspected Autoimmune Encephalitis: A Report of Two Cases
- 2026-08Kappa Free Light Chain for Diagnosis and Neurofilament Light Chain for Prognosis in Autoimmune Encephalitis
- 2026-08Diagnostic odyssey in type B Kufs disease: From autoimmune encephalitis mimicry to a frontotemporal dementia phenotype
- 2026-08Autoimmune encephalitis in older adults: Atypical presentation, therapeutic approaches and implication for diagnostic criteria
- 2026-08Risk factors for the progression to epilepsy following acute-phase autoimmune encephalitis with seizures: A two-center retrospective study
- 2026-08病例报告Lymphoplasmapheresis for Refractory Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report
- 2026-08病例报告Basal Ganglia Lesion Associated With Faciobrachial Dystonic Seizures (FBDS) in Anti-LGI1 Encephalitis: A Clinicopathological Case Report
- 2026-08综述The role of the gut microbiome in mediating neuroinflammation in immune-based neurological disorders
- 2026-07Challenges in Porphyria diagnosis and management: When variegate Porphyria meets HIV
- 2026-07病例报告Copine-5-IgG-related autoimmune encephalitis: a novel paraneoplastic neurological syndrome with a strong melanoma association
- 2026-07病例报告Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Mimicking Central Nervous System Infection in an Adolescent: A Case Report
- 2026-07Autoimmune encephalitis in eastern China over last decade: a multi-center retrospective study
- 2026-07Fifteen years of autoimmune encephalitis in Denmark: incidence, epidemiology, and trends in treatment
- 2026-07Seronegative Morvan Syndrome Presenting With Agrypnia Excitata and Peripheral Nerve Hyperexcitability: A Phenotype-Supported Diagnostic and Therapeutic Approach in a Resource-Limited Setting
- 2026-07病例报告Anti leucine-rich glioma-inactivated 1 (LGI1) antibody-positive limbic encephalitis with evolving basal ganglia T1WI hyperintensity: A case report
- 2026-07综述Research Advances and Biological Features of IgA for Immune-Related Diseases
- 2026-07Presenting and residual movement disorders in all-cause autoimmune encephalitis
- 2026-07病例报告NMDA Receptor-Associated Encephalitis and Renal Failure - A Unique Association
- 2026-07Pediatric stroke-like episodes temporally associated with pollen exposure in GJB1-related CMTX1: an expanded family case report with serial MRI and DTI follow-up
- 2026-07Revisiting intensity normalization in brain [<sup>18</sup>F]FDG PET: What is reliable in autoimmune encephalitis?
境外已获批用于本病的药物 0L2
欧盟与美国均未检索到已获批用于本病的药物。
已获孤儿药资格、尚未获批的在研药物（1 项）
孤儿药资格只是一种监管身份——它意味着监管机构认可这是罕见病用药并给予研发激励，不代表这个药已被证明有效，也不代表将来一定能上市。绝大多数最终不会成药。列在这里是为了看清有哪些方向正在被尝试。
- satralizumab-mwge美国2022-07-18Treatment of N-methyl-D-asparatate receptor (NMDAR) antibody autoimmune encephalitis (AIE)官方记录
数据来自欧洲药品管理局（EMA）的药品与孤儿药资格公开导出表，以及美国 FDA 孤儿药资格数据库。两边口径不同：欧盟一侧取的是当前状态仍为「已授权」的药品；美国一侧记录的是「曾获批准」这一事实，FDA 的公开表不追踪药物此后是否退市（例如 Relyvrio 于 2024 年撤市，表中仍记为已获批）。请以官方记录页为准。
在中国开展的临床试验 24L2
按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。
登记为可入组 14
- 招募中NCT04561557Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous System中国研究中心 1 个：Wuhan
- 招募中NCT06173076A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis中国研究中心 1 个：Hangzhou
- 招募中NCT06388161Neural Autoantibody Prevalence in New-onset Focal Seizures of Unknown Etiology中国研究中心 1 个：Hangzhou
- 招募中NCT07653984Cohort Study on Neuroimmune Diseases in the Reproductive Age中国研究中心 1 个：Guangzhou
- 招募中NCT06502015Biomarkers in Autoimmune Disease of Nervous System中国研究中心 1 个：Wuhan
- 招募中NCT06584045Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis)中国研究中心 1 个：Wuhan
- 招募中NCT06867991Safety and Efficacy of Combined B Cell Depleting theRapy And Daratumumab In Autoimmune Encephalitis中国研究中心 2 个：Changzhou、Zhengzhou
- 招募中NCT06510283Efficacy and Safety of Taitacept in Treatment of Refractory or Recurrent Anti-NMDAR/anti-LGI1 Encephalitis中国研究中心 1 个：Beijing
- 尚未开始招募NCT06760091A Multicentric Cohort of Autoimmune Encephalitis中国研究中心 1 个：Beijing
- 招募中NCT06939166Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases中国研究中心 1 个：Tianjin
- 招募中NCT07337785CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases中国研究中心 1 个：Wuhan
- 尚未开始招募NCT07333196Tongji NADs Cohort中国研究中心 1 个：Wuhan
- 招募中NCT07526493Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.中国研究中心 1 个：Wuhan
- 尚未开始招募NCT07686042Efficacy and Safety of Low-Dose Blinatumomab in the Treatment of Refractory Autoimmune Encephalitis and Autoimmune Cerebellitis中国研究中心 1 个：Beijing
其他状态的试验（10 项）
- 状态未知NCT02443350Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in Beijing Area中国研究中心 1 个：Beijing
- 已完成NCT07722286Relapse and Functional Outcomes in Anti-LGI1 Encephalitis中国研究中心 1 个：Hangzhou
- 已完成NCT03530462To Explore Cognitive Neural Mechanism of Autoimmune Encephalitis by Using Neuropsychological Tests and Multi-modal MRI中国研究中心 1 个：Hangzhou
- 状态未知NCT05422664Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy中国研究中心 1 个：Xi'an
- 已完成NCT03542279CPI Combination Therapy for Autoimmune Encephalitis中国研究中心 1 个：Beijing
- 状态未知NCT06443333National, Multicentric Registry Study on Neuroimmunological Diseases in China中国研究中心 1 个：Beijing
- 已完成NCT07036042Clinical Characteristics of Patients With Anti-Collapsin Response Mediator Protein 2 Antibodies in Encephalitis or Encephalomyelitis中国研究中心 1 个：Guangzhou
- 状态未知NCT05414890Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen Determination中国研究中心 1 个：Beijing
- 进行中·不再招募NCT05503264A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis中国研究中心 8 个：Beijing、Chengdu、Fuzhou、Jining、Shanghai、Wenzhou
- 已完成NCT06033846Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis中国研究中心 1 个：Xi'an
中国境外的在招试验 42L2
这些试验在中国没有研究中心，通常无法直接报名——入组一般要求在当地居住并接受随访。列在这里是因为它另有用处：看清楚全世界正在试哪些药、做到了哪一期、由谁在做。把药名和 NCT 编号记下来去问主治医生，或据此进一步查该药是否已在境外获批、是否有拓展性用药（expanded access）通道。
法国9美国7意大利3西班牙2埃及1韩国1加拿大1荷兰1德国1瑞士1
CT.gov 报告命中 42 项，此处取回并展示最近的 15 项。
- 尚未开始招募NCT07707739Plasma Exchange in Pediatric Autoimmune Encephalitis埃及
- 尚未开始招募NCT07583641A Study to Learn About How Well the Medicine Efgartigimod Works to Treat Autoimmune Encephalitis In Children 12 Years or Older and Adults美国
- 招募中NCT07732907Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia美国
- 招募中NCT07093333A Study in Participants With Anti-NMDAR Encephalitis and Anti-NMDAR Autoantibody-Associated Psychiatric Disease韩国
- 招募中NCT07488117Is [18F]-DPA-714 PET a Good Marker of Neuroinflammation in Autoimmune Encephalitis?法国
- 尚未开始招募NCT07341828A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy
- 招募中NCT07158229Long-term Impact of NMDAR Encephalitis, Level 3法国
- 招募中NCT06863974High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in Immune Cell Network法国
- 尚未开始招募NCT07131683hUC-MSC-Exo Therapy for Autoimmune Encephalitis
- 招募中NCT07477015Study of Pathogenic Mechanisms and Identification of Novel Autoantibodies in Autoimmune Encephalitis意大利
- 尚未开始招募NCT0685114318F-DPA-714 PET/MR in Dysfunctional Brain Diseases
- 尚未开始招募NCT06697678Risk Prediction Model for Severe Autoimmune Encephalitis
- 招募中NCT06941584Analysis of the Role of AIRE in Autoimmune Neurological Diseases Associated With Autoantibodies意大利
- 招募中NCT07133113Medium-term Effects of Treatments in Autoimmune Encephalitis法国
- 招募中NCT06079294Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism法国
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01；本条目在该版本中无中文名
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）