多灶性运动神经病

定义 英文原文（暂无中文）

Multifocal motor neuropathy (MMN) is a rare acquired immune-mediatedneuropathy characterized clinically by a purely motor deficit with conduction block and asymmetric multifocal weakness, fasciculations, and cramping.

别名

多灶性运动神经病伴传导阻滞

基本事实

遗传方式

未知

发病年龄

成年期

患病率

1-9 / 100 000

临床表型 12

近两年的全球研究 279L2

2024/10 起在 Europe PMC 检索所得，按发表时间倒序显示最近 20 篇。标题未译成中文——自动翻译需要接入 LLM 服务，尚未引入。

• 2026-09
  The role of leukocyte p38 MAP kinase in immune-mediated peripheral polyneuropathies: distinct modulation by intravenous immunoglobulins
  Journal of neurology · DOI · Europe PMC
• 2026-09综述开放获取
  Neurovascular Unit Dysfunction and Neural Barrier Pathology in Dysautonomia: Molecular Links to Cardiovascular Autonomic Failure
  International journal of molecular sciences · DOI · Europe PMC
• 2026-09系统综述开放获取
  Comparative efficacy, safety, and functional recovery of neonatal fc receptor inhibitors and conventional immunotherapies for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and network meta-analysis
  Frontiers in immunology · DOI · Europe PMC
• 2026-09
  Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue
  Journal of clinical apheresis · DOI · Europe PMC
• 2026-09开放获取
  High Resolution 3-T Magnetic Resonance Tractography Cannot Localise Conduction Block in Multifocal Motor Neuropathy With Conduction Block
  Journal of the peripheral nervous system : JPNS · DOI · Europe PMC
• 2026-09开放获取
  Unexpected Conduction Blocks in <i>SORD</i>-Related Distal Motor Neuropathy: A Case Report
  Clinical case reports · DOI · Europe PMC
• 2026-09
  Spectrum of Hereditary Neuropathies in Adult Patients From Serbia
  Journal of the peripheral nervous system : JPNS · DOI · Europe PMC
• 2026-08荟萃分析系统综述开放获取
  Effects of therapeutic plasma exchange (TPE) on efficacy and adverse events in patients with autoimmune neurological diseases: a systematic review and meta-analysis based on real-world studies and single-arm clinical trials
  Frontiers in neurology · DOI · Europe PMC
• 2026-08综述开放获取
  Magnetic resonance imaging applications to amyotrophic lateral sclerosis beyond the central nervous system
  Frontiers in neurology · DOI · Europe PMC
• 2026-08综述开放获取
  A cardiovascular-motor axis framework for perfusion-mediated motor impairment
  International journal of cardiology. Heart & vasculature · DOI · Europe PMC
• 2026-08
  Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% as Maintenance Therapy for Japanese Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: A Phase 3, Open-label Clinical Trial
  Internal medicine (Tokyo, Japan) · DOI · Europe PMC
• 2026-08综述开放获取
  Diffusion-Weighted Imaging in the Musculoskeletal System: Evolving Role in Modern Imaging Practice
  Diagnostics (Basel, Switzerland) · DOI · Europe PMC
• 2026-08病例报告开放获取
  An Unusual Iatrogenic Complication of Botulinum Toxin: Forearm Flexor Weakness Following a Nonstandard Intradermal Sensitivity Test
  Aesthetic surgery journal. Open forum · DOI · Europe PMC
• 2026-08综述开放获取
  The Role of Neurofilaments in Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis
  Journal of clinical medicine · DOI · Europe PMC
• 2026-08病例报告开放获取
  Ganglioside Antibodies as Formidable Neurologic Mimickers: A Case Report of Dual Anti-GQ1b and Asialo-GM1 Antibody Syndrome
  Cureus · DOI · Europe PMC
• 2026-08病例报告开放获取
  Bilateral Parsonage-Turner Syndrome in a Young Adult Man Due to Parvovirus B19 Infection
  Cureus · DOI · Europe PMC
• 2026-08开放获取
  Neuralgic amyotrophy - Beyond the plexus: A case of surgical treatment of bilateral distal peripheral nerve involvement in neuralgic amyotrophy/Parsonage-Turner Syndrome
  Brain & spine · DOI · Europe PMC
• 2026-08病例报告开放获取
  Cladribine treatment in chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy: two case reports
  Frontiers in immunology · DOI · Europe PMC
• 2026-08综述开放获取
  MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions
  Immunology · DOI · Europe PMC
• 2026-08开放获取
  Refining Electrophysiological Criteria in CIDP and MMN: Toward a Unified Definition of Motor Conduction Block and Proximal Temporal Dispersion
  European journal of neurology · DOI · Europe PMC

境外已获批用于本病的药物 1L2

欧盟 0 项、美国 1 项。同一药物在两地各批一次的，会分别列出。

• Gammagard Liquid美国2012-06-22
  immune globulin infusion (human)
  官方记录

数据来自欧洲药品管理局（EMA）的药品与罕见病用药资格公开导出表，以及美国 FDA 的罕见病用药资格数据库（Orphan Drug Product Designation Database）。两边口径不同：欧盟一侧取的是当前状态仍为「已授权」的药品；美国一侧记录的是「曾获批准」这一事实，FDA 的公开表不追踪药物此后是否退市（例如 Relyvrio 于 2024 年撤市，表中仍记为已获批）。请以官方记录页为准。

在中国开展的临床试验 3L2

按病名在 ClinicalTrials.gov 检索、并校验研究中心含中国大陆而来。登记状态不等于现在真的能入组——务必按 NCT 号到原站核实，并与主治医生商量。

当前没有检索到登记为可入组的试验。

中国境外的在招试验 2L2

共 2 项。

• 招募中NCT07610564
  A Study to Assess the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor Neuropathy
  I 期 · 干预性 · 2026/07/27argenx
  Georgia
• 招募中NCT01793168
  Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
  观察性 · 2010/07Sanford Health
  澳大利亚、美国

外部标识与链接