Childhood-onset schizophrenia
ORPHA:641496疾病暂无中文名
定义 英文原文(暂无中文)
A rare neurologic disease with psychiatric involvement characterized by prominent pre-psychotic developmental disabilities (cognitive, language, motor), socio-communicative disturbances, auditory hallucinations (visual and tactile hallucinations are rarer) preceding psychotic symptoms, presenting before 13 years of age. Co-occurrence of neurodevelopmental disorders (e.g. autism spectrum disorders, attention deficit hyperactivity disorder) is frequent. Disease course is more severe than adult-onset form of the disease, with major neurodevelopmental impact.
别名
COS、VEOS、Very early-onset schizophrenia
基本事实
- 遗传方式
- 多基因/多因素
- 发病年龄
- 青少年期、儿童期
- 患病率
- 1-5 / 10 000(Europe)
临床表型 20
极常见 99–80%1
- 精神病 HP:0000709
常见 79–30%10
- 意志力异常减退 HP:0000745
- 注意力缺陷多动障碍 HP:0007018
- 自闭症行为 HP:0000729
- 认知功能损害 HP:0100543
- 妄想 HP:0000746
- 社交互动减少 HP:5200310
- 形式思维过程紊乱 HP:0025769
- 幻觉 HP:0000738
- 执行功能受损 HP:0033051
- 偏执狂 HP:0011999
偶见 29–5%9
- 物质使用成瘾 HP:0033511
- 抑郁 HP:0000716
- 额颞叶萎缩 HP:0006892
- 全面发育迟缓 HP:0001263
- 侧脑室扩张 HP:0006956
- 缄默症 HP:0002300
- 自杀意念 HP:0031589
- 自杀行为 HP:5200330
- 言语混乱 HP:0025784
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
- 中文病名:Orphanet 中文包,冻结于 2020-06-01;本条目在该版本中无中文名
- 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)