B细胞慢性淋巴细胞白血病
B-cell chronic lymphocytic leukemia
定义 英文原文（暂无中文）
B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.
别名
B细胞慢性淋巴细胞白血病
基本事实
- 遗传方式
- 多基因/多因素、不适用
- 发病年龄
- 成年期
- 患病率
- 1-5 / 10 000（Europe）
相关基因 10
| 基因 | 名称 | 关联类型 |
|---|---|---|
| CCND1 | cyclin D1 | Part of a fusion gene in |
| TP53 | tumor protein p53 | Disease-causing somatic mutation(s) in |
| ARL11 | ARF like GTPase 11 | Major susceptibility factor in |
| ATM | ATM serine/threonine kinase | Disease-causing somatic mutation(s) in |
| IGHG1 | immunoglobulin heavy constant gamma 1 (G1m marker) | Part of a fusion gene in |
| IGHV3-21 | immunoglobulin heavy variable 3-21 | Biomarker tested in |
| POT1 | protection of telomeres 1 | Disease-causing somatic mutation(s) in |
| RPS15 | ribosomal protein S15 | Disease-causing somatic mutation(s) in |
| IKZF3 | IKAROS family zinc finger 3 | Disease-causing somatic mutation(s) in |
| P2RX7 | purinergic receptor P2X 7 | Biomarker tested in |
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）