自由生活阿米巴所致阿米巴病
Amoebiasis due to free-living amoebae
定义 英文原文（暂无中文）
A rare parasitic disease caused by free-living amoebae belonging to the Acanthamoeba, Naegleria and Balamuthia genera, that are able to survive in an autonomous state in all natural environments and can also parasitize humans. In immunosuppressed individuals Acanthamoeba genus contamination leads to granulomatous amoebic encephalitis (also reported in association with species of the Balamuthia genus) together with other problems including cardiac, cutaneous and pulmonary manifestations, all of which influence the prognosis. In immunocompetent individuals, the Naegleria fowleri species is responsible for primary amoebic meningoencephalitis, the evolution of which is rapidly fatal.
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 各年龄段
- 患病率
- 1-9 / 100 000（Europe）
临床表型 68
常见 79–30%13
- 脑脊液形态异常 HP:0002921
- 非典型行为 HP:0000708
- 脑成像异常 HP:0410263
- 脑脊液淋巴细胞增生症 HP:0200149
- 发热 HP:0001945
- 头痛 HP:0002315
- 脑脊液蛋白浓度增加 HP:0002922
- 传染性脑炎 HP:0002383
- 恶心 HP:0002018
- 性格改变 HP:0000751
- 畏光 HP:0000613
- 癫痫发作 HP:0001250
- 呕吐 HP:0002013
偶见 29–5%32
- 外展神经麻痹 HP:0006897
- 基底节形态异常 HP:0002134
- 脑干核磁共振信号强度异常 HP:0012747
- 小脑形态异常 HP:0001317
- 脑白质形态异常 HP:0002500
- 颅神经生理异常 HP:0031910
- 下丘脑形态异常 HP:0012286
- 中脑形态异常 HP:0002418
- 大脑皮层形态异常 HP:0002538
- 延髓形态异常 HP:0011441
- 桥脑形态异常 HP:0007361
- 脊髓形态异常 HP:0002143
- 失语症 HP:0002381
- 脑水肿 HP:0002181
- 意识模糊 HP:0001289
- 复视 HP:0000651
- 面部不对称 HP:0000324
- 面部神经麻痹 HP:0010628
- 第四组颅神经麻痹 HP:0007011
- 肉芽肿 HP:0032252
- 轻偏瘫 HP:0001269
- 免疫缺陷 HP:0002721
- 颅内压增高 HP:0002516
- 红细胞计数增高 HP:0020059
- 易激惹 HP:0000737
- 昏睡 HP:0001254
- 意识丧失 HP:0007185
- 颈部僵硬 HP:0031179
- 动眼神经麻痹 HP:0012246
- 坐立不安 HP:0000711
- 颈部僵硬 HP:0025258
- 视力丧失 HP:0000572
罕见 <4–1%23
- 味觉异常 HP:0000223
- 肾上腺异常 HP:0000834
- 心律失常 HP:0011675
- 共济失调 HP:0001251
- 失明 HP:0000618
- 昏迷 HP:0001259
- 结膜充血 HP:0030953
- 角膜穿孔 HP:0100583
- 角膜溃疡 HP:0012804
- 脑软化症 HP:0040197
- 嗅觉减退 HP:0004409
- 泪液产量增加 HP:0031731
- 肾内脓肿 HP:0032620
- 心肌坏死 HP:0001700
- 眼痛 HP:0200026
- 丘疹 HP:0200034
- 肺炎 HP:0002090
- 脓疱 HP:0200039
- 呼吸道感染 HP:0011947
- 鼻窦炎 HP:0000246
- 皮肤溃疡 HP:0200042
- 皮下结节 HP:0001482
- 非寻常皮肤感染 HP:0032162
外部标识与链接
发现这一页有错误？告诉我 · 邮件主题会自动带上本页的 ORPHA 编号
本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）