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血管圆线虫病

Angiostrongyliasis

ORPHA:74疾病

定义 英文原文(暂无中文)

A foodborne zoonotic disease, endemic to Southeast Asia and the Pacific Islands, caused by the rat lungworm Angiostrongylus cantonensis and that is acquired by the ingestion of the infective larvae on vegetables or in raw or undercooked snails, slugs, land crabs, freshwater shrimps, frogs and lizards. The main feature is eosinophilic meningitis, with clinical manifestations including fever, headache, malaise, fatigue, vomiting, rhinorrhea, blurred vision, diplopia, cough, stiff neck, enteritis, constipation and paraesthesia due to the movement of the worms from the intestines to the lungs, central nervous system and eyes. In severe cases without treatment, coma and death can occur.

基本事实

遗传方式
不适用
发病年龄
各年龄段

临床表型 39

极常见 99–80%3

  • 脑脊液细胞增多 HP:0012229
  • 头痛 HP:0002315
  • 高嗜酸性粒细胞 HP:0032061

常见 79–30%19

  • 腹痛 HP:0002027
  • 关节疼痛 HP:0002829
  • 脑成像异常 HP:0410263
  • 便秘 HP:0002019
  • 复视 HP:0000651
  • 日间睡眠增多 HP:0001262
  • 疲乏 HP:0012378
  • 发热 HP:0001945
  • 胃肠道嗜酸性粒细胞增多症 HP:0032064
  • 颅内压增高 HP:0002516
  • 易激惹 HP:0000737
  • 脑膜炎 HP:0001287
  • 肌痛 HP:0003326
  • 感觉异常 HP:0003401
  • 食欲不振 HP:0004396
  • 喷射性呕吐 HP:0002587
  • 颈部僵硬 HP:0025258
  • 不寻常的中枢神经系统感染 HP:0011450
  • 呕吐 HP:0002013

偶见 29–5%15

  • 视力模糊 HP:0000622
  • 脑水肿 HP:0002181
  • 远端肌无力 HP:0002460
  • 循环IgA水平升高 HP:0003261
  • 循环IgG水平升高 HP:0003237
  • 循环IgM水平升高 HP:0003496
  • 循环特异性IgE抗体水平升高 HP:0032336
  • 肌无力 HP:0001324
  • 恶心 HP:0002018
  • 颈痛 HP:0030833
  • 颈部僵硬 HP:0031179
  • 疼痛 HP:0012531
  • 瘙痒 HP:0000989
  • 癫痫发作 HP:0001250
  • 巨脑室 HP:0002119

罕见 <4–1%2

  • 昏迷 HP:0001259
  • 感觉过敏 HP:0100963

外部标识与链接

OrphanetMONDO:0019143GARD:683ICD-10 B81.3、B83.2ICD-11 1F60、1F60.0、1F60.1、1F60.YClinicalTrials.gov 检索

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本页数据来源

  • 疾病定义、同义词、基因、表型、流行病学:Orphanet(CC BY 4.0)
  • 中文病名:Orphanet 中文包,冻结于 2020-06-01
  • 表型中文标签:HPO 简体中文翻译(CHPO 上游成果)