特发性指甲粗糙脆裂
Idiopathic trachyonychia
ORPHA:79153疾病
定义 英文原文（暂无中文）
A rare isolated nail anomaly characterized by brittle, thin, rough, opaque appearing nails with excessive longitudinal ridging. In a less severe form, the nails retain their luster and present with superficial ridging and multiple small geometric pits. In both varieties, superficial scaling of the nail plate and hyperkeratosis of the cuticles, as well as koilonychia and onychoschizia are observed. Any number of nails may be affected, and fingernails are more often affected than toenails. Spontaneous improvement of the condition may occur.
基本事实
- 遗传方式
- 常染色体显性
- 发病年龄
- 儿童期
临床表型 17
极常见 99–80%1
- 甲营养不良 HP:0008404
常见 79–30%7
- 甲周异常 HP:0100803
- 反甲 HP:0001598
- 指甲发育不良 HP:0100798
- 脆甲 HP:0001808
- 甲凹点 HP:0001803
- 甲纵嵴 HP:0001807
- 薄甲 HP:0001816
偶见 29–5%3
- 甲周皮肤角化过度 HP:0008399
- 片形脱发，鬼剃头 HP:0002232
- 趾甲发育不良 HP:0100797
罕见 <4–1%5
- 淀粉样变 HP:0011034
- 特应性皮炎 HP:0001047
- 自身免疫性血小板减少症 HP:0001973
- 鱼鳞病 HP:0008064
- 白癜风 HP:0001045
排除 0%1
- 疼痛 HP:0012531
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）