T细胞幼淋巴细胞白血病

定义 英文原文（暂无中文）

A rare mature T-cell neoplasm characterized by proliferation of small to medium-sized prolymphocytes with a mature post-thymic T-cell phenotype, involving the peripheral blood, bone marrow, lymph nodes, liver, spleen, and sometimes the skin. T-cell receptor genes are clonally rearranged. Patients typically present with hepatosplenomegaly, generalized lymphadenopathy, high leukocyte count with normal serum immunoglobulins, anemia, and thrombocytopenia. HTLV-1 serology is negative. The disease course is aggressive with generally poor prognosis.

别名

T细胞慢性淋巴细胞白血病

基本事实

遗传方式

不适用

发病年龄

成年期、老年期

外部标识与链接