早产儿败血症
Sepsis in premature infants
定义 英文原文（暂无中文）
A rare systemic condition affecting neonates born at less than 37 weeks gestational age and characterized by life-threatening organ dysfunction caused by a dysregulated host response to an infection, which may have been acquired shortly before or during birth (resulting in early-onset neonatal sepsis during the first 72 hours of life), or after birth (leading to late-onset neonatal sepsis between 72 hours and three months). Prematurity constitutes one of the primary risk factors for neonatal sepsis. The clinical picture may develop gradually with signs and symptoms like irritability, lethargy, or poor feeding, or progress rapidly to respiratory distress, fever, hypothermia, hypotension, shock, and multiple organ failure.
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 新生儿期
- 患病率
- 1-5 / 10 000（Europe）
临床表型 51
极常见 99–80%5
- 免疫系统功能异常 HP:0010978
- 新生儿败血症 HP:0040187
- 早产 HP:0001622
- 小于胎龄儿 HP:0001518
- 心动过速 HP:0001649
常见 79–30%17
- 腹胀 HP:0003270
- 纤毛清除功能异常 HP:0031602
- 剖腹产 HP:0011410
- 体重下降 HP:0004325
- 中性粒细胞减少症 HP:0001875
- 呼吸困难 HP:0002094
- C-反应蛋白水平升高 HP:0011227
- 发热 HP:0001945
- 胃肠道功能异常 HP:0012719
- 胃肠动力障碍 HP:0002579
- 低体温 HP:0002045
- 循环白细胞介素6水平升高 HP:0030783
- 白细胞增多症 HP:0001974
- 代谢性酸中毒 HP:0001942
- 新生儿肌张力减退 HP:0001319
- 苍白圈 HP:0000980
- 重度感染 HP:0032169
偶见 29–5%26
- 异常出血 HP:0001892
- 呼吸系统生理异常 HP:0002795
- 前囟形态异常 HP:0000236
- 贫血 HP:0001903
- 心动过缓 HP:0001662
- 紫绀 HP:0000961
- 肝功能下降 HP:0001410
- 腹泻 HP:0002014
- 水肿 HP:0000969
- 小肠结肠炎 HP:0004387
- 肝脏肿大 HP:0002240
- 腱反射减弱 HP:0001265
- 低血压 HP:0002615
- 黄疸 HP:0000952
- 脑膜炎 HP:0001287
- 鼻翼煽动 HP:0030863
- 少尿症 HP:0100520
- 瘀点 HP:0000967
- 孕史 HP:0002686
- 紫癜 HP:0000979
- 可逆性肾功能衰竭 HP:0004713
- 癫痫发作 HP:0001250
- 脾肿大 HP:0001744
- 体温不稳定 HP:0005968
- 血小板减少症 HP:0001873
- 呕吐 HP:0002013
罕见 <4–1%3
- 急性弥散性血管内凝血 HP:0011880
- 播散性病毒感染 HP:0031696
- 侵袭性真菌感染 HP:0020101
外部标识与链接
发现这一页有错误？告诉我 · 邮件主题会自动带上本页的 ORPHA 编号
本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）