前体T细胞急性淋巴细胞白血病
Precursor T-cell acute lymphoblastic leukemia
ORPHA:99861疾病
定义 英文原文（暂无中文）
A rare acute lymphoblastic leukemia characterized by a neoplasm of lymphoblasts committed to the T-cell lineage, involving bone marrow and blood. A value of >25% bone marrow blasts may be used to define leukemia (as opposed to lymphoma) in cases with the presence of a mass lesion in addition to bone marrow involvement. Patients typically present with leukocytosis, and frequently with a large mediastinal or other tissue mass. Lymphadenopathy and hepatosplenomegaly are common.
别名
前体T细胞急性淋巴细胞白血病/淋巴瘤
基本事实
- 遗传方式
- 不适用
- 发病年龄
- 青少年期、成年期
相关基因 22
| 基因 | 名称 | 关联类型 |
|---|---|---|
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | Part of a fusion gene in |
| BCR | BCR activator of RhoGEF and GTPase | Part of a fusion gene in |
| CDKN2A | cyclin dependent kinase inhibitor 2A | Disease-causing somatic mutation(s) in |
| TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | Part of a fusion gene in |
| FLT3 | fms related receptor tyrosine kinase 3 | Disease-causing somatic mutation(s) in |
| MYC | MYC proto-oncogene, bHLH transcription factor | Part of a fusion gene in |
| NUP214 | nucleoporin 214 | Part of a fusion gene in |
| STIL | STIL centriolar assembly protein | Part of a fusion gene in |
| MYB | MYB proto-oncogene, transcription factor | Part of a fusion gene in |
| TRB | T-cell receptor beta locus | Part of a fusion gene in |
| TRA | T-cell receptor alpha locus | Part of a fusion gene in |
| TRD | T-cell receptor delta locus | Part of a fusion gene in |
| TCL1A | TCL1 family AKT coactivator A | Part of a fusion gene in |
| TLX1 | T cell leukemia homeobox 1 | Part of a fusion gene in |
| TLX3 | T cell leukemia homeobox 3 | Part of a fusion gene in |
| CNOT3 | CCR4-NOT transcription complex subunit 3 | Disease-causing somatic mutation(s) in |
| MLLT10 | MLLT10 histone lysine methyltransferase DOT1L cofactor | Part of a fusion gene in |
| DDX3X | DEAD-box helicase 3 X-linked | Part of a fusion gene in |
| PICALM | phosphatidylinositol binding clathrin assembly protein | Part of a fusion gene in |
| ZBTB16 | zinc finger and BTB domain containing 16 | Part of a fusion gene in |
| SALL2 | spalt like transcription factor 2 | Part of a fusion gene in |
| SET | SET nuclear proto-oncogene | Part of a fusion gene in |
外部标识与链接
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本页数据来源
- 疾病定义、同义词、基因、表型、流行病学：Orphanet（CC BY 4.0）
- 中文病名：Orphanet 中文包，冻结于 2020-06-01
- 表型中文标签：HPO 简体中文翻译（CHPO 上游成果）